Research progress in RNA interference against the infection of mosquito-borne viruses
Received date: 2019-10-15
Revised date: 2019-12-14
Online published: 2020-01-07
Supported by
National Natural Science Foundation of China(31630011);Natural Science Foundation of Guangdong Province of China(2017A030313625);Science and Technology Planning Project of Guangzhou City(201804020084)
Mosquito-borne diseases have become an important public health issue of global concern because of their high incidence and transmission rate. As a vector for mosquito-borne diseases, studying the interaction mechanism between mosquitoes and mosquito-borne viruses will help control mosquito-borne diseases. The impaired innate immunity and immune barriers evasion caused by mosquito-borne viruses in mosquitoes pose a potential risk for the persistent infection of the virus in mosquitoes and the outbreak of mosquito-borne diseases. The RNA interference (RNAi) pathway, as a powerful antiviral defense barrier in mosquitoes, can inhibit viral replication and transmission by producing a variety of small RNAs to degrade viral RNA. In this review, we summarize the related studies on the innate immune mechanism against mosquito- borne virus infection in mosquitoes about small interfering RNA (siRNA), microRNA (miRNA), and Piwi-interacting RNA (piRNA), aiming to provide a theoretical reference for the prevention and control of mosquito-borne diseases.
Key words： Mosquito; Mosquito-borne viruses; siRNA; miRNA; piRNA
Yong Wei, Yulan He, Xueli Zheng . Research progress in RNA interference against the infection of mosquito-borne viruses[J]. Hereditas(Beijing), 2020 , 42(2) : 153 -160 . DOI: 10.16288/j.yczz.19-262
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