Molecular genetic mechanisms of interaction between host plants and pathogens
Received date: 2020-01-13
Revised date: 2020-02-19
Online published: 2020-03-01
Supported by
Supported by the Youth Technology Innovation Team of the Fujian Academy of Agricultural Sciences No(STIT2017-3-3);the Special Fund for Agro-scientific Research in the Public Interest of Fujian Province No(2017R1021-2);Fujian Provincial Natural Science Foundation No(2019J01102);the Free Exploration Project of the Fujian Academy of Agricultural Sciences No(AA2018-21)
In recent years, a great number of plant resistance (R) genes and pathogen avirulence (Avr) genes were identified. Exciting breakthroughs were also made on the structural and functional analysis of R proteins and Avr proteins, and the mechanistic interaction between them. Plants have evolved two layers of the immune system to cope with pathogens in the evolutionary processes, which are pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and effector-triggered immunity (ETI). In PTI responses, conserved PAMPs are recognized by plant plasma membrane-localized pattern recognition receptors (PRRs) and disease resistance is activated. Furthermore, the ETI immune signaling is activated by the recognition of pathogen Avr proteins by the host R proteins, which usually results in hypersensitive responses at the infection site. In this review, we summarize the progresses on PTI and ETI, and discuss the genetic mechanism of the interaction between plant R gene and pathogen Avr gene in detail. We also envision the new challenges and propose the new strategies for the future investigations on plant resistance molecular breeding.
Key words： plant; Resistance gene; Avirulence gene; interaction; breeding utilization research
Dewei Yang, Shengping Li, Haitao Cui, Shenghao Zou, Wei Wang . Molecular genetic mechanisms of interaction between host plants and pathogens[J]. Hereditas(Beijing), 2020 , 42(3) : 278 -286 . DOI: 10.16288/j.yczz.20-015
| [1] | Ausubel FM . Are innate immune signaling pathways in plants and animals conserved? Nat Immunol, 2005,6(10):973-979. |
| [2] | Jones JD, Dangl JL . The plant immune system. Nature, 2006,444(7117):323-329. |
| [3] | Dangl JL, Jones JD . Plant pathogens and integrated defence responses to infection. Nature, 2001,411(6839):826-833. |
| [4] | Gómez-Gómez L, Boller T . FLS2: an LRR receptor-like kinase involved in the perception of the bacterial elicitor flagellin in Arabidopsis. Mol Cell, 2000, ( 6):1003-1011. |
| [5] | Chinchilla D, Zipfel C, Robatzek S, Kemmerling B, Nürnberger T, Jones JDG, Felix G, Boller T . A flagellin- induced complex of the receptor FLS2 and BAK1 initiates plant defence. Nature, 2007,448(7152):497-500. |
| [6] | Sun YD, Li L, Macho AP, Han ZF, Hu ZH, Zipfel C, Zhou JM, Chai JJ . Structural basis for flg22-induced activation of the Arabidopsis FLS2-BAK1 immune complex. Science, 2013,342(6158):624-628. |
| [7] | Zipfel C, Kunze G, Chinchilla D, Caniard A, Jones JD, Boller T, Felix G . Perception of the bacterial PAMP EF-Tu by the receptor EFR restricts Agrobacterium- mediated transformation. Cell, 2006,125(4):749-760. |
| [8] | Boller T, Felix G . A renaissance of elicitors: perception of microbe-associated molecular patterns and danger signals by pattern-recognition receptors. Annu Rev Plant Biol, 2009,60:379-406. |
| [9] | Pfeilmeier S, George J, Morel A, Roy S, Smoker M, Stransfeld L, Downie JA, Peeters N, Malone JG, Zipfel C . Expression of the Arabidopsis thaliana immune receptor EFR in Medicago truncatula reduces infection by a root pathogenic bacterium, but not nitrogen-fixing rhizobial symbiosis. Plant Biotechnol J, 2019,17(3):569-579. |
| [10] | Shimizu T, Nakano T, Takamizawa D, Desaki Y, Ishii- Minami N, Nishizawa Y, Minami E, Okada K, Yamane H, Kaku H, Shibuya N . Two LysM receptor molecules, CEBiP and OsCERK1, cooperatively regulate chitin elicitor signaling in rice. Plant J, 2010,64(2):204-214. |
| [11] | Liu J, Liu B, Chen SF, Gong BQ, Chen LJ, Zhou Q, Xiong F, Wang ML, Feng DR, Li JF, Wang HB, Wang JF . A tyrosine phosphorylation cycle regulates fungal activation of a plant receptor Ser/Thr Kinase. Cell Host Microbe, 2018,23(2):241-253. |
| [12] | Ao Y, Li ZQ, Feng DR, Xiong F, Liu J, Li JF, Wang ML, Wang JF, Liu B, Wang HB . OsCERK1 and OsRLCK176 play important roles in peptidoglycan and chitin signaling in rice innate immunity. Plant J, 2014,80(6):1072-1084. |
| [13] | Dixon MS, Jones DA, Keddie JS, Thomas CM, Harrison K, Jones JD . The tomato Cf-2 disease resistance locus comprises two functional genes encoding leucine-rich repeat proteins. Cell, 1996,84(3):451-459. |
| [14] | Luderer R , Takken FLW, de Wit PJGM, Joosten MHA[J]. Cladosporium fulvum overcomes Cf-2-mediated resistance by producing truncated AVR2 elicitor proteins. Mol Microbiol, 2002,45(3):875-884. |
| [15] | Dixon MS, Golstein C, Thomas CM, van Der Biezen EA, Jones JD . Genetic complexity of pathogen perception by plants: the example of Rcr3, a tomato gene required specifically by Cf-2. Proc Natl Acad Sci USA, 2000,97(16):8807-8814. |
| [16] | van der Hoorn RAL, Kamoun S . From guard to decoy: a new model for perception of plant pathogen effectors. Plant Cell, 2008,20(8):2009-2017. |
| [17] | Johal GS, Briggs SP . Reductase activity encoded by the HM1 disease resistance gene in maize. Science, 1992,258(5084):985-987. |
| [18] | Kourelis J, van der Hoorn RAL . Defended to the nines: 25 years of resistance gene cloning identifies nine mechanisms for R protein function. Plant Cell, 2018,30(2):285-299. |
| [19] | Chisholm ST, Dahlbeck D, Krishnamurthy N, Day B, Sjolander K, Staskawicz BJ . Molecular characterization of proteolytic cleavage sites of the Pseudomonas syringae effector AvrRpt2. Proc Natl Acad Sci USA, 2005,102(6):2087-2092. |
| [20] | Axtell MJ, Staskawicz BJ . Initiation of RPS2-specified disease resistance in Arabidopsis is coupled to the AvrRpt2-directed elimination of RIN4. Cell, 2003,112(3):369-377. |
| [21] | Deslandes L, Olivier J, Peeters N, Feng DX, Khounlotham M, Boucher C, Somssich I, Genin S, Marco Y . Physical interaction between RRS1-R, a protein conferring resistance to bacterial wilt, and PopP2, a type III effector targeted to the plant nucleus. Proc Natl Acad Sci USA, 2003,100(13):8024-8029. |
| [22] | Keen NT . Gene-for-gene complementarity in plant-pathogen interactions. Annu Rev Genet, 1990,24:447-463. |
| [23] | Jia Y, McAdams SA, Bryan GT, Hershey HP, Valent B. Direct interaction of resistance gene and avirulence gene products confers rice blast resistance. EMBO J, 2000,19(15):4004-4014. |
| [24] | Saur IM, Bauer S, Kracher B, Lu X, Franzeskakis L, Müller MC, Sabelleck B, Kümmel F, Panstruga R, Maekawa T, Schulze-Lefert P . Multiple pairs of allelic MLA immune receptor-powdery mildew AVRA effectors argue for a direct recognition mechanism. eLife, 2019,e44471. |
| [25] | van der Biezen EA, Jones JD . Plant disease-resistance proteins and the gene-for-gene concept. Trends Biochem Sci, 1998,23(12):454-456. |
| [26] | Tasset C, Bernoux M, Jauneau A, Pouzet C, Brière C, Kieffer-Jacquinod S, Rivas S, Marco Y, Deslandes L . Autoacetylation of the Ralstonia solanacearum effector PopP2 targets a lysine residue essential for RRS1-R- mediated immunity in Arabidopsis. PLoS Pathog, 2010,6(11):1-14. |
| [27] | Mackey D, Holt BF, Wiig A, Dangl JL . RIN4 interacts with Pseudomonas syringae type III effector molecules and is required for RPM1-mediated resistance in Arabidopsis. Cell, 2002,108(6):743-754. |
| [28] | Day B, Dahlbeck D, Huang J, Chisholm ST, Li D, Staskawicz BJ . Molecular basis for the RIN4 negative regulation of RPS2 disease resistance. Plant Cell, 2005,17(4):1292-1305. |
| [29] | Chinchilla D, Bauer Z, Regenass M, Boller T, Felix G . The Arabidopsis receptor kinase FLS2 binds flg22 and determines the specificity of flagellin perception. Plant Cell, 2006,18(2):465-476. |
| [30] | Dodds PN, Rathjen JP . Plant immunity: Towards an integrated view of plant-pathogen interactions. Nat Rev Genet, 2010,11(8):539-548. |
| [31] | Zhang J, Li W, Xiang TT, Liu ZX, Laluk K, Ding XJ, Zou Y, Gao MH, Zhang XJ, Chen S, Mengiste T, Zhang YL, Zhou JM . Receptor-like cytoplasmic kinases integrate signaling from multiple plant immune receptors and are targeted by a Pseudomonas syringae effector. Cell Host Microbe, 2010,7(4):290-301 |
| [32] | Shao F, Golstein C, Ade J, Stoutemyer M, Dixon JE, Innes RW . Cleavage of Arabidopsis PBS1 by a bacterial type III effector. Science, 2003,301(5637):1230-1233. |
| [33] | Césari S, Thilliez G, Ribot C, Chalvon V, Michel C, Jauneau A, Rivas S, Alaux L, Kanzaki H, Okuyama Y, Morel JB, Fournier E, Tharreau D, Terauchi R, Kroj T . The rice resistance protein pair RGA4/RGA5 recognizes the Magnaporthe oryzae effectors AVR-Pia and AVR1-CO39 by direct binding. Plant Cell, 2013,25(4):1463-1481. |
| [34] | Maqbool A, Saitoh H, Franceschetti M, Stevenson CEM, Uemura A, Kanzaki H, Kamoun S, Terauchi R, Banfield MJ . Structural basis of pathogen recognition by an integrated HMA domain in a plant NLR immune receptor. eLife, 2015,4:e08709. |
| [35] | Fukuoka S, Saka N, Koga H, Ono K, Shimizu T, Ebana K, Hayashi N, Takahashi A, Hirochika H, Okuno K, Yano M . Loss of function of a proline-containing protein confers durable disease resistance in rice. Science, 2009,325(5943):998-1001. |
| [36] | Le Roux C, Huet G, Jauneau A, Camborde L, Trémousaygue D, Kraut A, Zhou B, Levaillant M, Adachi H, Yoshioka H, Raffaele S, Berthomé R, Couté Y, Parker JE, Deslandes L . A receptor pair with an integrated decoy converts pathogen disabling of transcription factors to immunity. Cell, 2015,161(5):1074-1088. |
| [37] | Ma ZC, Zhu L, Song TQ, Wang Y, Zhang Q, Xia YQ, Qiu M, Lin YC, Li HY, Kong L, Fang YF, Ye WW, Wang Y, Dong SM, Zheng XB, Tyler BM, Wang YC . A paralogous decoy protects Phytophthora sojae apoplastic effector PsXEG1 from a host inhibitor. Science, 2017,355(6326):710-714. |
| [38] | Schornack S, Meyer A, R?mer P, Jordan T, Lahaye T . Gene-for-gene-mediated recognition of nuclear-targeted AvrBs3-like bacterial effector proteins. J Plant Physiol, 2006,163(3):256-272. |
| [39] | Gu KY, Yang B, Tian DS, Wu LF, Wang DJ, Sreekala C, Yang F, Chu ZQ, Wang GL, White FF, Yin ZC . R gene expression induced by a type-III effector triggers disease resistance in rice. Nature, 2005,435(7045):1122-1125. |
| [40] | R?mer P, Hahn S, Jordan T, Strauss T, Bonas U, Lahaye T . Plant pathogen recognition mediated by promoter activation of the pepper Bs3 resistance gene. Science, 2007,318(5850):645-648. |
| [41] | Chen H, Chen J, Li M, Chang M, Xu KM, Shang ZH, Zhao Y, Palmer I, Zhang YQ, McGill J, Alfano JR, Nishimura MT, Liu FQ, Fu ZQ. A bacterial type III effector targets the master regulator of salicylic acid signaling, NPR1, to subvert plant immunity. Cell Host Microbe, 2017,22(6):777-788. |
| [42] | Lopez VA, Park BC, Nowak D, Sreelatha A, Zembek P, Fernandez J, Servage KA, Gradowski M, Hennig J, Tomchick DR, Paw?owski K, Krzymowska M, Tagliabracci VS. A bacterial effector mimics a host HSP90 client to undermine immunity. 2019, Cell, 179(1): 205- 218.e21. |
| [43] | Boch J, Scholze H, Schornack S, Landgraf A, Hahn S, Kay S, Lahaye T, Nickstadt A, Bonas U . Breaking the code of DNA binding specificity of TAL-type III effectors. Science, 2009; 326(5959):1509-1512. |
| [44] | He F, Wang CC, Wang FQ, Yang L . Interaction mechanism between plant resistance gene and pathogen avirulence gene. Chin J Cell Biol, 2011,33(9):1037-1044. |
| [44] | 何锋, 王长春, 王锋青, 杨玲 . 植物抗病基因(R)与病原物无毒基因(Avr)相互作用机制的研究进展. 中国细胞生物学学报, 2011,33(9):1037-1044. |
| [45] | Yang DW, Wang M, Hang LB, Tang DZ, Li SP . Progress of cloning and breeding application of blast resistance genes in rice and avirulence genes in blast fungi. Chin Bull Bot, 2019, 54(2):265-276. |
| [45] | 杨德卫, 王莫, 韩利波, 唐定中, 李生平 . 水稻稻瘟病抗性基因的克隆、育种利用及稻瘟菌无毒基因研究进展. 植物学报, 2019,54(2):265-276. |
| [46] | He F, Zhang H, Liu JL, Wang ZL, Wang GL . Recent advances in understanding the innate immune mechanisms and developing new disease resistance breeding strategies against the rice blast fungus Magnaporthe oryzae in rice. Hereditas(Beijing), 2014,36(8):756-765. |
| [46] | 何峰, 张浩, 刘金灵, 王志龙, 王国梁 . 水稻抗稻瘟病天然免疫机制及抗病育种新策略. 遗传, 2014,36(8):756-765. |
| [47] | Narusaka M, Shirasu K, Noutoshi Y, Kubo Y, Shiraishi T, Iwabuchi M, Narusaka Y . RRS1 and RPS4 provide a dual resistance-gene system against fungal and bacterial pathogens. Plant J, 2009,60(2):218-226. |
/
| 〈 |
|
〉 |
www.chinagene.cn
备案号：京ICP备09063187号
