Structural and functional characteristics of plant PHD domain-containing proteins
Received date: 2020-12-01
Revised date: 2021-02-09
Online published: 2021-03-10
Supported by
Supported by the National Natural Science Foundation of China No(31925005)
Plant homeodomain (PHD) is a class of transcription factor in the Zinc finger domain family. The most important function of which is to recognize various histone modifications, including histone methylation and acetylation, etc. They can also bind to DNA. Proteins with PHD domains, some of which possess histone modification enzyme activity, or can interact with histone modification enzymes, and some are associated with DNA methylation, with E3 ubiquitin ligase activity, or even can be chromatin remodeling factors. As transcriptional regulators, they play an important role in plant growth and development. In this review, we summarize the structural features and substrate binding specificity of PHD domains (including H3K4me3/0, H3K9me3, H3R2, H3K14ac) and DNA, the conservation of plant PHD domain in evolution, the molecular mechanism of known PHD domain-containing proteins in plants, providing a reference for further understanding of the involvement of these proteins during plant growth and development.
Tianyi Wang, Yingxiang Wang, Chenjiang You . Structural and functional characteristics of plant PHD domain-containing proteins[J]. Hereditas(Beijing), 2021 , 43(4) : 323 -339 . DOI: 10.16288/j.yczz.20-412
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