Epigenetic “reader” BET proteins regulate mammalian development and iPSC reprogramming
Received date: 2021-06-30
Revised date: 2021-08-23
Online published: 2021-10-26
Supported by
Supported by the National Natural Science Foundation of China No(31671545)
As an epigenetic “reader”, bromodomain and extra-terminal (BET) proteins play a vital role in mammalian development. Each member in the BET family regulates precisely the related genes and promotes the differentiation and development of early embryos specifically through recognizing a variety of epigenetic modifications and recruiting corresponding functional complexes. In addition, with the development of induced pluripotent stem cell (iPSC) technology, accumulating evidence have found that BET family proteins may also play a pivotal role in the iPSC reprogramming. In this review, we summarize the function of the BET family proteins in mammalian development and iPSC reprogramming from recent literatures and speculate new mechanisms of the BET family proteins in regulating reprogramming.
Zhijing Zhang, Yu Qiao, Yuchen Sun, Lei Lei . Epigenetic “reader” BET proteins regulate mammalian development and iPSC reprogramming[J]. Hereditas(Beijing), 2022 , 44(1) : 36 -45 . DOI: 10.16288/j.yczz.21-232
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