Pan-genome: setting a new standard for high-quality reference genomes
Received date: 2021-08-26
Revised date: 2021-10-28
Online published: 2021-10-28
Supported by
Supported by the National Natural Science Foundation of China No(31822052)
With the release of high-quality reference genomes assembled by long reads from the third-generation sequencing technology, as well as extensive re-sequencing and population genetic analysis, researchers found that a single reference genome does not represent the diversity within a species. The missing sequences on the reference genome result in an incomplete population genetic polymorphism map. The emergence of pan-genome can well repair the deficiency of single reference genome, which include core genome (responsible for basic biological functions and the main phenotypic characteristics within a species) and the variable genome (related to the genetic diversity or biological characteristics). According to the core and variable genome proportion, the types of pan-genomes can be either open or closed. Here, we review the current exploring of pan-genome for a range of species, to discuss the characteristics of pan-genome in various biological groups. The pan-genome of mammals are more likely closed, while the pan-genomes of microbes, angiosperms, and some invertebrates are likely non-closed. It is possible to complete the reference genome and obtain complete variation information through the pan-genomic study, which will contribute to the study of molecular mechanism for genetic diversity and phenotypic evolution.
Key words： pan-genome; presence and absence variations; core genome; variable genome
Peipei Bian, Yu Zhang, Yu Jiang . Pan-genome: setting a new standard for high-quality reference genomes[J]. Hereditas(Beijing), 2021 , 43(11) : 1023 -1037 . DOI: 10.16288/j.yczz.21-214
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