The regulatory effect of protein acetylation modification on autophagy
Received date: 2021-09-13
Revised date: 2021-12-01
Online published: 2021-12-02
Supported by
Supported by the National Natural Science Foundation of China No(31600934)
Autophagy is a highly conserved material degradation pathway from yeast to humans that depends on vacuoles or lysosomes. It plays an important role in the maintenance of homeostasis, and its dysfunction is closely related to the pathogenesis of major diseases, such as neurodegenerative disorders, metabolic diseases, and malignant tumors. As an important biological process for the maintenance of homeostasis, autophagy is highly regulated. Acetylation of proteins is a reversible post-translational modification and plays an important role in the regulation of autophagy. In this review, we summarize research results on the modulation of acetylation in the regulation of autophagy and aim to provide insights into this biological process for the advancement of the basic research and development of preventive and therapeutic strategies against autophagy-related diseases.
Key words： autophagy; acetylation; autophagy-related proteins
Jing Liu, Cong Yi, Shiming Xu . The regulatory effect of protein acetylation modification on autophagy[J]. Hereditas(Beijing), 2022 , 44(1) : 15 -24 . DOI: 10.16288/j.yczz.21-329
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