The role of histone demethylases of KDM7 family in brain-related disorders
Received date: 2021-10-01
Revised date: 2021-12-21
Online published: 2022-01-04
Supported by
Supported by the National Natural Science Foundation of China Nos(81971792);Supported by the National Natural Science Foundation of China Nos(81901920);the China Postdoctoral Science Foundation No(2019M663746);the Natural Science Basic Research Program of Shaanxi Province No(2020JQ-091)
The histone demethylases of KDM7 family, including KDM7A, KDM7B and KDM7C, regulate transcription through acting on specific histone lysines. Previous studies have shown that these family members are functionally important for the processes of neural differentiation and tumor development, and little is known about their roles in brain neurological diseases. In this review, we summarize the latest research progress of KDM7 family on their epigenetic regulation mechanisms, their protein structures and their functions in brain-related diseases, which will likely advance our understanding of the molecular mechanisms of neurological diseases.
Key words： histone lysine demethylases; KDM7; H3K9me2; H3K27me2
Zhuojin Yang, Yuxiang Zhang, Xixi Yang, Feifei Gao, Jingsi Yang, Chunxia Yan . The role of histone demethylases of KDM7 family in brain-related disorders[J]. Hereditas(Beijing), 2022 , 44(1) : 25 -35 . DOI: 10.16288/j.yczz.21-280
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