Genetic substructure analysis of three isolated populations in southwest China
Received date: 2022-01-13
Revised date: 2022-03-20
Online published: 2022-03-29
Supported by
Supported by the Special for basic work of science and technology No(2015FY111700);the National Natural Science Foundation of China Nos(31271283);the National Natural Science Foundation of China Nos(31401022);the National Key Research and Development Program of the Ministry of Science and Technology No(2016YFF0202301)
Southwest China is home to numerous ethnic minorities, as well as many geographically and genetically isolated groups. However, the genetic substructure of these ethnic groups, especially the paternal genetic structure between groups, has not been comprehensively analyzed. In this study, we used Y chromosome capture and Illumina sequencing technologies to investigate the paternal genetic structure of three isolated groups of male unrelated individuals, including Baima in Pingwu, Sichuan Province, Muya in Shimian, Sichuan Province, and Kongge in Jinghong, Yunnan Province. We calculated the frequencies of related haplogroups by the fixed-point compound amplification method and direct counting method, and used the Past3.0 software to perform principal component analysis to draw a population clustering tree. we observed that Kongge had 3 Y chromosome haplogroups, Baima had 4 Y chromosome haplogroups, and Muya had 5 Y chromosome haplogroups. The results showed that Kongge was most closely related to the Wa, and the Y chromosome types of the Baima and Muya were mainly concentrated in the D haplogroup and its lower reaches. It has the closest relationship with the Tibetans in Qamdo and Nyingchi. The study on the genetic structure of different ethnic groups has enriched the genetic relationship of isolated populations and provided a new perspective for understanding Chinese ethnic groups.
Fei Wang, Meng Wang, Xinghua Zhang, Keli Yu, Lianbin Zheng, Yajun Yang . Genetic substructure analysis of three isolated populations in southwest China[J]. Hereditas(Beijing), 2022 , 44(5) : 424 -431 . DOI: 10.16288/j.yczz.22-013
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