The nuclear receptor REV-ERBα integrates circadian clock and energy metabolism
Received date: 2022-09-26
Revised date: 2022-11-09
Online published: 2022-11-23
Supported by
the National Natural Science Foundation of China(92057112);the National Key Research and Development Program of China(2021YFF0702000)
The physiological processes of mammals show rhythmic changes in a 24-h cycle. Circadian rhythms are under the subtle control of the autonomous circadian clock, and dysregulation of the circadian system can lead to health problems such as metabolic disorders. REV-ERBα, a member of the nuclear receptor superfamily, is an important component of the mammalian circadian clock. REV-ERBα regulates various physiological processes, including the regulation of metabolism, inflammation and immunity as well as the circadian rhythm, making it a potential therapeutic target for metabolic syndrome, inflammatory diseases and cancers. In recent years, an array of new REV-ERBα ligands have been discovered, most of which have potential applications in the treatment of diseases. In this review, we focus on the regulatory role of nuclear receptor REV-ERBα in energy metabolism and inflammation, in order to provide new strategies for the therapy of metabolic syndrome and its related diseases.
Key words： REV-ERBα; metabolism; inflammation; REV-ERBα ligands
Mao Shuyu, Zhao Changrui, Liu Chang . The nuclear receptor REV-ERBα integrates circadian clock and energy metabolism[J]. Hereditas(Beijing), 2023 , 45(2) : 99 -114 . DOI: 10.16288/j.yczz.22-310
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