Application of Hi-C technology in three-dimensional genomics research and disease pathogenesis analysis
Received date: 2022-12-25
Revised date: 2023-02-11
Online published: 2023-02-22
Supported by
National Natural Science Foundation of China(82170896);Innovative Science and Technology Team of Shannxi Province(2022TD-44)
3D genomics aims to investigate the spatial structure of chromatin in the nucleus on the basis of genomic sequences, gene structures and relevant regulatory elements. The spatial organization of chromosomes is fundamental for gene expression regulation. Recent advances of high-throughput chromosome conformation capture (Hi-C) technology and its derivatives, has enabled capture of chromatin architecture with high resolution. In this review, we summarize the development and applications of various technologies of 3D genomes in disease research, particularly in the elucidation of pathogenic mechanisms in cancers and other systemic disorders.
Key words： Hi-C; 3D genomics; chromatin structure; regulation of gene expression
Shunze Wang, Feng Jiang, Dongli Zhu, Tie-Lin Yang, Yan Guo . Application of Hi-C technology in three-dimensional genomics research and disease pathogenesis analysis[J]. Hereditas(Beijing), 2023 , 45(4) : 279 -294 . DOI: 10.16288/j.yczz.22-390
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