Pathogenesis and therapeutic advances of cerebral autosomal- dominant arteriopathy with subcortical infarcts and leukoencephalopathy
Received date: 2023-02-01
Revised date: 2023-04-27
Online published: 2023-05-09
Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary cerebral small vessel disease in adults. Many CADASIL cases were reported after NOTCH3 was identified as the causative gene of CADASIL. However, there is still no specific and effective therapies for CADASIL. In this review, we summarize recent research progress on disease models, symptomatic treatments and potential therapies for CADASIL, thereby providing a reference for follow-up CADASIL treatment research.
Key words： CADASIL; pathogenesis
Yi Zhang, Zhi-Ying Wu . Pathogenesis and therapeutic advances of cerebral autosomal- dominant arteriopathy with subcortical infarcts and leukoencephalopathy[J]. Hereditas(Beijing), 2023 , 45(7) : 568 -579 . DOI: 10.16288/j.yczz.23-023
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