Received date: 2023-08-07
Revised date: 2023-09-21
Online published: 2023-10-12
Supported by
Emergency Key Program of Guangzhou Laboratory(EKPG21-19);Open Cooperation Project of Nanjing Medical University Global Health Center(JX103SYL202200313)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes a broad clinical spectrum of coronavirus disease 2019 (COVID-19). Genetic factors might influence susceptibility to the SARS-CoV-2 infection or disease severity. Genome-wide association studies (GWASs) have identified multiple susceptible genes related to COVID-19 phenotypes, providing the scientific basis for the COVID-19 prevention and treatment. In this review, we summarize the recent progresses of COVID-19 susceptible genes, including the GWASs on multiple phenotypes of COVID-19, GWASs of COVID-19 in multiple ethnic populations, GWASs of COVID-19 based on multiple types of genetic variations, and the fine-mapping of the regions surrounding the susceptible genes.
Key words： SARS-CoV-2; COVID-19; Susceptibility gene
Yuanfeng Li, Tianzhun Wu, Shunqi Chen, Yuting Wang, Tao Zeng, Ruofan Li, Gangqiao Zhou . Progresses on genetic susceptibility of COVID-19[J]. Hereditas(Beijing), 2023 , 45(11) : 963 -975 . DOI: 10.16288/j.yczz.23-215
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