Research progress on the effect of sperm chromatin integrity on function and its detection methods
Received date: 2024-04-21
Revised date: 2024-06-29
Online published: 2024-07-05
Supported by
Baoding Science and Technology Plan Project(2341ZF280);Doctor Fund of Baoding No.1 Central Hospital
Sperm chromatin not only carries genetic information such as paternal DNA, but also carries structural proteins, epigenetic information, and higher-order chromatin structures (such as matrix attachment regions and telomeres), etc. These information play an important role in embryonic development. This article mainly reviews the effects of these different information carried by sperm chromatin on sperm function and embryonic development and the research progress of related detection methods, in order to provide a theoretical basis and scientific diagnosis and treatment strategies for the etiology screening of clinical infertility, embryo arrest and recurrent miscarriage, so as to improve the pregnancy outcomes of natural conception and assisted reproduction. Keywords: sperm chromatin; epigenetics; sperm DNA damage; sperm function; higher-order chromatin structures
Daiyuan Liu, Zhaohui Zhang, Xianjiang Kang . Research progress on the effect of sperm chromatin integrity on function and its detection methods[J]. Hereditas(Beijing), 2024 , 46(7) : 511 -529 . DOI: 10.16288/j.yczz.24-106
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