Abstract: In this paper PCR-SSCP technique was used to analyze the polymorphisms of the tenth exon of GHR gene in Qinchuan cattle. The results showed that PCR products demonstrated polymorphisms in Qinchuan cattle and the population was at Hardy-Weinberg equilibrium (P > 0.05). There were three allele gene A、B、C in this locus with the corresponding frequencies of 0.5956, 0.2905 and 0.1140. The amplified fragments of homozygosis genotype were sequenced. The result showed that there were two mutation in these fragments. Then the relationship between genotypes and productive perform-ances was analyzed by the Least Squire Method (LSM). The results showed that some productive performances of the indi-viduals with genotype AB were higher than those of the other genotypes, and the derivation was significant among geno-types. It suggested that GHR gene may be a candidate gene responsible for growth trait in Qinchuan cattle.