血清miRNAs作为食管鳞癌新的生物标志物

doi:10.16288/j.yczz.14-441

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HEREDITAS(Beijing) ›› 2015, Vol. 37 ›› Issue (4): 315-320.doi: 10.16288/j.yczz.14-441

• Reviews • Next Articles

Serum miRNAs as new biomarkers for esophageal squamous cell carcinoma

Yingying Li¹,Zhiguang Liu²,Li Wang¹,Yuanyuan Yuan¹,Ping Liu²,Linsong Wang¹

1. College of Life Sciences, Henan Normal University, Xinxiang 453007, China;
2. Surgical Oncology, Xinxiang Central Hospital, Xinxiang 453000, China

Received:2014-12-15 Online:2015-04-20 Published:2015-03-12

Abstract

Abstract: Esophageal squamous cell carcinoma (ESCC) is one of the most common types of malignancies in China. Most ESCC patients are diagnosed at middle to late stages with poor prognosis due to the lack of an effective method for early diagnosis. MicroRNAs (miRNAs) are a family of endogenous small non-coding RNAs that can regulate ESCC development and progression by repressing their specific target genes’ expression. Compared to traditional biomarkers (e.g., mRNAs and proteins), miRNAs are more stable and can be readily screened and accurately quantitated and analyzed, making them ideal new-generation of biomarkers for early cancer detection and prognostic evaluation. Recent studies have shown that the changes of the expression levels of some serum miRNAs from ESCC patients significantly correlate with their diagnostic and prognostic outcome. In this review, we summarize the trend of the expression changes of miRNAs in ESCC patients’ serum and discuss the possibility of detecting these miRNAs’ expression changes as a novel method for ESCC early diagnosis and prognostic evaluation. Notably, the results of serum miRNAs from different detection methods are not completely consistent. Thus, we also discuss several possible reasons for such inconsistency.

Key words: serum, miRNA, esophageal squamous cell carcinoma

Yingying Li,Zhiguang Liu,Li Wang,Yuanyuan Yuan,Ping Liu,Linsong Wang. Serum miRNAs as new biomarkers for esophageal squamous cell carcinoma[J]. HEREDITAS(Beijing), 2015, 37(4): 315-320.

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Serum miRNAs as new biomarkers for esophageal squamous cell carcinoma

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