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Hereditas(Beijing) ›› 2017, Vol. 39 ›› Issue (11): 1090-1101.doi: 10.16288/j.yczz.17-116

• Orginal Article • Previous Articles     Next Articles

Screening weight related genes of velvet antlers by whole genome re-sequencing

Pengfei Hu1(),Jiaping Xu1,Cheng Ai2,Xiujuan Shao2(),Hongliang Wang1,Yimeng Dong3,Xuezhe Cui1,Fuhe Yang1,Xiumei Xing1   

  1. 1. State Key Laboratory for Molecular Biology of Special Economic Animals, Key Laboratory of Special Economic Animal Genetics and Breeding, Ministry of Agriculture, Institute of Special Economic Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China
    2. Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China
    3. Jilin Agricultural University, Changchun 130118, China
  • Received:2017-03-30 Revised:2017-06-11 Online:2017-11-20 Published:2017-12-20
  • Supported by:
    the Science and Technology Development Project of Jilin Province(20150309006YY)

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Abstract:

The velvet antler is a special organ that has important biological significance for deer, and its growth is a complicated biological metabolism process. Growing evidence suggests that genetics factors play essential roles in the weight of velvet antlers. In this study, we investigated five sika deer (Cervus nippon) populations under the same feeding condition, and screened genetic variations in the 100 samples (including 50 heavy and 50 light velvet antler weight samples) by whole genome re-sequencing. The results showed that 94 genetic variations were related to the velvet antler weight, among which two single nucleotide polymorphism (SNP) sites were located on the exon regions of OAS2 and ALYREF/THOC4, respectively. Furthermore, ALYREF/THOC4 is highly expressed in the velvet antler. The biological functions of these genetic variations were highly related to the growth and development of deer velvet antlers. Collectively, we screened genes related to the velvet antler weight in sika deer populations by whole genome re-sequencing and identified 94 sites as candidate genetic variations related to the velvet antler weight. We hope that it will contribute to further mechanistic studies of velvet antler development and weight variations.

Key words: whole genome re-sequencing, Cervus nippon, velvet antler weight, genome wide association study