细胞终末分化过程中三维基因组结构与功能调控的分子机制

doi:10.16288/j.yczz.19-270

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Hereditas(Beijing) ›› 2020, Vol. 42 ›› Issue (1): 32-44.doi: 10.16288/j.yczz.19-270

• Special Section: 3D Genome • Previous Articles Next Articles

Molecular mechanism of the 3D genome structure and function regulation during cell terminal differentiation

Ke Yang, Zheng Xue, Xiang Lv()

State Key Laboratory of Medical Molecular Biology, Department of Pathophysiology, Institute of Basic Medical Sciences, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China

Received:2019-09-05 Revised:2019-12-13 Online:2020-01-20 Published:2019-12-25
Contact: Lv Xiang E-mail:lvxiang@pumc.edu.cn
Supported by:
Supported by the National Key Research and Development Program for Stem Cells and Transformation Research No(2016YFA0100603);Chinese Academy of Medical Sciences Medical and Health Science and Technology Innovation Engineering Collaborative Innovation Team Project No(2016-I2M-3-002);General Program of the National Natural Science Foundation of China No(81670108)

Abstract

Abstract:

The eukaryotic chromatin is folded into highly complex three-dimensional (3D) structures, which plays an important role in the precise regulation of gene expression and normal physiological function. During differentiation and terminal maturation, cells usually undergo dramatic morphology and gene expression changes, accompanied by significant changes in the 3D structure of the genome. In this review, we provide a comprehensive view of the spatial hierarchical organization of the genome, including chromosome territories, A/B compartment, topologically associating domains (TADs) and looping, focusing on recent progresses in the dynamic 3D genomic structural changes and functional regulation during cell differentiation and terminal maturation. In the end, we summarize the unsolved issues as well as prospects of the 3D genome research in cell differentiation and maturation.

Key words: 3D genome, A/B compartment, topologically associating domain (TAD), looping, cell terminal differentiation

Ke Yang, Zheng Xue, Xiang Lv. Molecular mechanism of the 3D genome structure and function regulation during cell terminal differentiation[J]. Hereditas(Beijing), 2020, 42(1): 32-44.

Figures/Tables 1

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Molecular mechanism of the 3D genome structure and function regulation during cell terminal differentiation

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