文昌鱼左右体轴建立机制的研究进展

doi:10.16288/j.yczz.20-246

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Hereditas(Beijing) ›› 2021, Vol. 43 ›› Issue (2): 134-141.doi: 10.16288/j.yczz.20-246

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Progress on the left-right asymmetry patterning in amphioxus

Guangwei Hu^1,²(), Zhenzhen Zhang^1,², Huan Gao^1,²

¹ Jiangsu Key Laboratory of Marine Bioresources and Environment /Jiangsu Key Laboratory of Marine Biotechnology School of Marine Science and Fisheries, Jiangsu Ocean University, Lianyungang 222005, China
² Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Ocean University, Lianyungang 222005, China

Received:2020-07-28 Online:2021-02-16 Published:2020-12-30
Supported by:
the National Natural Science Foundation of China(31900370);the Natural Science Foundation of Jiangsu Province(BK20191007);and the Priority Academic Program Development Fund of Jiangsu Higher Education Institutions(PAPD)

Abstract

Abstract:

The mechanisms underlying the establishment of left-right (L-R) asymmetry in bilaterians is one of the central enigmas in developmental biology. Amphioxus is an important model in studying the mechanisms of animal asymmetry specification due to its particular phylogenetic position, vertebrate-like embryogenesis and body plan. Recently, with the establishments of artificial breeding technology, high-efficiency microinjection method and gene knockout technology, researchers have successfully dissected the mechanisms of amphioxus L-R asymmetry development. In this review, we summarize the major progress in understanding L-R asymmetry specification in amphioxus and propose a model of regulation of L-R asymmetry in this species. Hh protein is transported dominantly to the right side by cilia movement, leading to R>L Hh signaling andCerexpression. Cer inhibits expression of Nodal, leading to the asymmetric expression of Nodal-dependent genes. The L-R differences in the propagation of the Nodal pathway result in the correct morphological L-R asymmetry development in amphioxus embryo. BMP signaling probably does not provide the asymmetric cue, but is necessary for correct expression ofCer andNodal.

Key words: amphioxus, L-R axis, embryonic development

Guangwei Hu, Zhenzhen Zhang, Huan Gao. Progress on the left-right asymmetry patterning in amphioxus[J]. Hereditas(Beijing), 2021, 43(2): 134-141.

Figures/Tables 2

References 55

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