前列腺素F2α受体(PTGFR)基因在白色杜洛克×二花脸资源群体中的遗传变异及其与母猪母性行为的关联性

doi:10.3724/SP.J.1005.2010.01147

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HEREDITAS ›› 2010, Vol. 32 ›› Issue (11): 1147-1152.doi: 10.3724/SP.J.1005.2010.01147

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Genetic variation and association of prostaglandin F2α receptor (PTGFR) gene with sow maternal behaviors in a White Duroc × Erhualian resource population

YANG Zhu-Qing, REN Jun, ZHANG Zhi-Yan, CHEN Cong-Ying

Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, Nanchang 330045, China

Received:2010-03-18 Revised:2010-04-27 Online:2010-11-20 Published:2010-11-25
Contact: CHEN Cong-Ying E-mail:chcy75@hotmail.com

Abstract

Abstract: Maternal behaviors of sows around parturition are important for survival of newborn offspring. Failure to establish normal maternal bonds such as maternal infanticide and crushing often occurs in some individuals. It causes both significant economic losses to the pig industry and severe problems of piglet welfare. Prostaglandin F2-alpha not only can stimulate the nest-building behavior of sows before parturition but also plays an important role in reproductive process and maternal behavior through protein FP encoded by the prostaglandin F receptor gene (PTGFR) as its receptor. In this study, genetic variation and association study of PTGFR gene with nest-building behavior, maternal infanticide, and crushing behavior was carried out in a White Duroc × Erhualian resource population. As a result, five synonymous mutations were identified on exon 1 and exon 2. Exon 1 g.250 A>G, Exon 1 g.619 G>A and Exon 2 g.483 T>C were chosen for genotyping in indi-viduals of F0, F1 and 289 F2 sows. Family-based transmission disequilibrium test (TDT) demonstrated that there were no significant associations of 3 SNPs and haplotypes of PTGFR gene with sow nest-building, maternal infanticide and crushing behavior (P > 0.05). Therefore, it can be concluded that PTGFR gene is not the causative candidate gene for sow maternal behaviors.

Key words: maternal infanticide, crushing behavior, nest-building behavior, PTGFR gene, resource population

YANG Zhu-Jing, LIN Jun, ZHANG Zhi-Yan, CHEN Cong-Yang. Genetic variation and association of prostaglandin F2α receptor (PTGFR) gene with sow maternal behaviors in a White Duroc × Erhualian resource population[J]. HEREDITAS, 2010, 32(11): 1147-1152.

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Genetic variation and association of prostaglandin F2α receptor (PTGFR) gene with sow maternal behaviors in a White Duroc × Erhualian resource population

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