[an error occurred while processing this directive]

HEREDITAS ›› 2006, Vol. 28 ›› Issue (11): 1361-1364.doi: 10.1360/yc-006-1361

• 研究报告 • Previous Articles     Next Articles

Genetic Polymorphism of 15 STR Loci in a Lhasa Tibetan Population

LI Ning1; SU Yu-Hong2; XI Huan-Jiu3; REN Fu3; ZHU Bao-Qin2; WEN You-Feng3   

  1. 1. College of Basic Science, Jinzhou Medical College, Liaoning Province, Jinzhou 121001, China; 2. Key Laboratory of Molecular
    Cell Biology and New Drug Development of Liaoning Province, Jinzhou Medical College, Liaoning Province, Jinzhou 121001, China;
    3. Anthropology Laboratory, Jinzhou Medical College, Liaoning Province, Jinzhou 121001, China
  • Received:2005-11-22 Revised:2006-01-09 Online:2006-11-05 Published:2006-11-05
  • Contact: XI Huan-Jiu

Abstract:

The polymorphism distributions of 15 STR loci (D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, VWA, TPOX, D18S51, D5S818 and FGA) were investigated in a Lhasa Tibetan population by multiplex PCR amplification using five fluorochromes (6FAM, VIC, NED, PET, LIZ). Gene frequency, discrimination power (DP), heterozygosity (H), polymorphism information content (PIC) and probability of paternity exclusion (EPP) were calculated, and all loci were tested for Hardy-Weinberg equilibrium. Results indicate that the gene frequency of these 15 STR loci is in Hardy-Weinberg equilibrium. The DP is at 0.7515-0.9599, H is at 0.5576-0.8538, PIC is at 0.5455-0.8458, and EPP isat 0.3755-0.8520. Cumulative DP of the 15 STR is 0.99999999, and cumulative EPP is 0.999999997. Therefore, these 15 STR loci can be used as genetic markers of in Lhasa Tibetan populations in anthropological studies, linkage analysis of genetic diseases, individual identification and paternity testing in forensic medicine.

CLC Number: