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HEREDITAS ›› 2007, Vol. 29 ›› Issue (5): 523-527.doi: 10.1360/yc-007-0523

• 综述 • Previous Articles     Next Articles

Research progress on nonsyndromic X-linked mental retardation related gene PAK3

GAO Xiao-Cai1,2 ; XI Geng-Si1 ; ZHANG Fu-Chang2

  

  1. 1. College of Life Science, Shaanxi Normal University, Xi’an 710062, China;
    2. Institute of Population and Health, College of Life Science, Northwest University, Xi’an 710069, China
  • Received:2006-08-30 Revised:2006-11-12 Online:2007-05-08 Published:2007-05-08
  • Contact: XI Geng-Si

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Abstract:

Mutations of the gene coding for PAK3 (p21-activated kinase 3) are associated with nonsyndromic X-linked mental retardation (MRX). It may be associated with generalized or specific cognitive ability. Studying the biological and cognitive function of PAK3 is important for MR diagnosis and prevention. This paper reviews the progress on PAK3 including its gene product, biological and cognitive function. The future directions on the study of PAK3 are also discussed.

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