小RNAs作用机制的研究进展

doi:10.3724/SP.J.1005.2009.01205

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HEREDITAS ›› 2009, Vol. 31 ›› Issue (12): 1205-1213.doi: 10.3724/SP.J.1005.2009.01205

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Advances in mechanism of small RNAs

XIE Zhao-Hui

Department of Biology, Dezhou University, Dezhou, Shandong Province 253023, China

Received:2009-04-30 Revised:2009-05-30 Online:2009-12-10 Published:2009-12-10
Contact: XIE Zhao-Hui E-mail:xiezhh0523@163.com

Abstract

Abstract:

The discovery of RNA interference (RNAi) heralded a revolution in RNA biology. Researchers uncovered ‘hidden’ layers of regulation of gene expression, in which many previously unidentified families of small RNAs (consisting of ~20–30 nucleotides) mediate gene silencing in transcriptional and post-transcriptional levels. In eukaryotes, these small RNAs, including siRNAs, miRNAs, piRNAs, scnRNAs, 21U-RNAs, and some others, regulate gene expression, helping to control cellular metabolism, growth, and differentiation, to maintain genome integrity, to regulate stem cell renewal, and to combat viruses and mobile genetic elements. This review summarizes the current advancement in the identification and biosynthesis of small RNAs and their roles in gene regulation.

Key words: siRNAs, miRNAs, piwiRNAs, scnRNAs, 21U-RNAs, advances

XIE Zhao-Hui. Advances in mechanism of small RNAs[J]. HEREDITAS, 2009, 31(12): 1205-1213.

References 24

[1]	Pereira TC, Lopes-Cendes I. RNAi-mediated gene silenc-ing as a principle of action of venoms and poisons. Med Hypotheses, 2008, 70(6): 1179-1181.
[2]	Rusk N. When microRNAs activate translation. Nat Methods, 2008, 5(2): 122-123.
[3]	Chu CY, Rana TM. Small RNAs: regulators and guardians of the genome. J Cell Physiol, 2007, 213(2): 412-419.
[4]	Willmann MR, Poethig RS. Conservation and evolution of miRNA regulatory programs in plant. Curr Opin Plant Biol, 2007, 10(5): 503-511.
[5]	Zhao T, Li G, Mi S, Li S, Hannon GJ, Wang XJ, Qi Y. A com-plex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii. Genes Dev, 2007, 21(10): 1190-1203.
[6]	Piriyapongsa J, Jordan IK. Dual coding of siRNAs and miRNAs by plant transposable elements. RNA, 2008, 14(5): 814-821.
[7]	Axtell MJ. Evolution of microRNAs and their targets: are all microRNAs biologically relevant? Biochim Biophys Acta, 2008, 1779(11): 725-734.
[8]	Chapman EJ, Carrington JC. Specialization and evolution of endogenous small RNA pathways. Nat Rev Genet, 2007, 8(11): 884-896.
[9]	Chuck G, Candela H, Hake S. Big impacts by small RNAs in plant development. Curr Opin Plant Biol, 2009, 12(1): 81-86.
[10]	Sheng Y, Engström PG, Lenhard B. Mammalian microRNA prediction through a support vector machine model of se-quence and structure. PLoS ONE, 2007, 2(9): e946.
[11]	Makeyev EV, Zhang J, Carrasco MA, Maniatis T. The microRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Mol Cell, 2007, 27(3): 435-448.
[12]	Tam OH, Aravin AA, Stein P, Girard A, Murchison EP, Cheloufi S, Hodges E, Anger M, Sachidanandam R, Schultz RM, Hannon GJ. Pseudogene-derived small inter-fering RNAs regulate gene expression in mouse oocytes. Nature, 2008, 453(7194): 534-538.
[13]	Sunkar R, Chinnusamy V, Zhu J, Zhu JK. Small RNAs as big players in plant abiotic stress responses and nutrient deprivation. Trends Plant Sci, 2007, 12(7): 301-309.
[14]	Shukla LI, Chinnusamy V, Sunkar R. The role of microRNAs and other endogenous small RNAs in plant stress responses. Biochim Biophys Acta, 2008, 1779(11): 743-748.
[15]	Piriyapongsa J, Jordan IK. Dual coding of siRNAs and miRNAs by plant transposable elements. RNA, 2008, 14(5): 814-821.
[16]	Shabalina SA, Koonin EV. Origins and evolution of eu-karyotic RNA interference. Trends Ecol Evol, 2008, 23(10): 578-587.
[17]	Cullen BR. Is RNA interference involved in intrinsic anti-viral immunity in mammals? Nat Immunol, 2006,7(6): 563-567.
[18]	Pedersen I, David M. MicroRNAs in the immune response. Cytokine, 2008, 43(3): 391-394.
[19]	Pedersen IM, Cheng G, Wieland S, Volinia S, Croce CM, Chisari FV, David M. Interferon modulation of cellular microRNAs as an antiviral mechanism. Nature, 2007, 449(7164): 919-922.
[20]	Mahajan VS, Drake A, Chen J. Virus-specific host miRNAs: antiviral defenses or promoters of persistent in-fection? Trends Immunol, 2009, 30(1): 1-7.
[21]	Peragine A, Yoshikawa M, Wu G, Albrecht HL. SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis. Genes Dev, 2004, 18(19): 2368-2379. [22] Axtell MJ, Snyder JA, Bartel DP, Common functions for diverse small RNAs of land plants. Plant Cell, 2007, 19(6): 1750-1769.
[23]	Nogueira FT, Madi S, Chitwood DH, Juarez MT, Timmermans MC. Two small regulatory RNAs establish opposing fates of a developmental axis. Genes Dev, 2007, 21(7): 750-755.
[24]	Tretter EM, Alvarez JP, Eshed Y, Bowma

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Advances in mechanism of small RNAs

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