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Hereditas(Beijing) ›› 2017, Vol. 39 ›› Issue (11): 1066-1077.doi: 10.16288/j.yczz.17-121

• Orginal Article • Previous Articles     Next Articles

Genetic and epigenetic regulation of PPARγ during adipogenesis

Tingting Cui1,2,3(),Tianyu Xing1,2,3,Yankan Chu1,2,3,Hui Li1,2,3,Ning Wang1,2,3()   

  1. 1. Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture, Harbin 150030, China
    2. Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, Harbin 150030, China
    3. Key Laboratory of Animal Cells and Genetic Engineering of Heilongjiang Province, Harbin 150030, China
  • Received:2017-03-30 Revised:2017-06-29 Online:2017-11-20 Published:2017-12-20
  • Supported by:
    the National Natural Science Foundation of China(31572392,31372299);the China Agriculture Research System(CARS-42)

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Abstract:

Peroxisome proliferator-activated receptor gamma (PPARγ) is the master regulator of adipogenesis and adipose tissue development. It also plays crucial roles in many other biological processes, including lipid and glucose metabolism and energy homeostasis. Recently, evidence has been accumulating that the PPARγ gene is not only genetically regulated, but also epigenetically regulated by DNA methylation, histone modification, non-coding RNA and chromosome remodeling. In this review, we summarize the advances in the genetic and epigenetic regulation of the PPARγ gene during adipogenesis, and discuss future research directions and trends for the study of its regulation.

Key words: PPARγ, adipogenesis, genetic regulation, epigenetic regulation, gene expression