中国人群参考基因组及基因组变异图谱资源库

doi:10.16288/j.yczz.18-177

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Hereditas(Beijing) ›› 2018, Vol. 40 ›› Issue (11): 1048-1054.doi: 10.16288/j.yczz.18-177

• Orginal Article • Previous Articles

Database resources of the reference genome and genetic variation maps for the Chinese population

Shuhui Song^1,^2,³,Xufei Teng^1,³,Jingfa Xiao^1,^2,³()

^1. BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
^2. CAS Key Laboratory of Genomics and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
^3. University of Chinese Academy of Sciences, Beijing 100049, China

Received:2018-05-24 Revised:2018-09-10 Online:2018-11-20 Published:2018-09-11
Contact: Xiao Jingfa E-mail:xiaojingfa@big.ac.cn
Supported by:
Supported by the National Natural Science Foundation of China(31771465);the 13th Five-year Informatization Plan of Chinese Academy of Sciences(XXH13505-05);Youth Innovation Promotion Association(2017141)

Abstract

Abstract:

With the implementation of the international human genome project and 1000 genome project, hundreds of Chinese individual genome sequences have been published. Establishing a high-precision Chinese population reference genome and identifying the unique genome variations are fundamental for future precision medicine research in China. To further meet the needs of scientific management and deep mining on the rapidly growing Chinese genomic data, Beijing Institute of Genomics, Chinese Academy of Sciences, has developed a Virtual Chinese Genome Database (VCGDB, http://bigd.big.ac.cn/vcg/) and Genome Variation Map (GVM, http://bigd.big.ac.cn/gvm/) based on the public whole genome sequencing data, which provides the worldwide services of data retrieval, sharing, downloading and online analysis. This paper presents the brief introduction of characteristics and functions of the two databases, as well as their future development and application prospects, aiming to provide useful information for the promotion and development of the reference genome and genome variation map database in China.

Key words: Chinese population, reference genome, variation map

Shuhui Song,Xufei Teng,Jingfa Xiao. Database resources of the reference genome and genetic variation maps for the Chinese population[J]. Hereditas(Beijing), 2018, 40(11): 1048-1054.

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