哺乳动物卵母细胞的DNA损伤与修复研究进展

doi:10.16288/j.yczz.23-018

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Hereditas(Beijing) ›› 2023, Vol. 45 ›› Issue (5): 379-394.doi: 10.16288/j.yczz.23-018

• Review • Previous Articles Next Articles

Advances in the study of DNA damage and repair in mammalian oocytes

Nan Zhang¹(), Jue Zhang², Ge Lin^1,²()

1. Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha 410000, China
2. Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha 410000, China

Received:2023-02-02 Revised:2023-03-23 Online:2023-05-20 Published:2023-03-29
Contact: Lin Ge E-mail:csudnn@csu.edu.cn;linggf@hotmail.com
Supported by:
the Fellowship of China Postdoctoral Science Foundation(2021M690983)

Abstract

Abstract:

DNA damage is one of the key factors affecting gametogenesis and embryo development. Oocytes are susceptible to DNA damage induced by various endogenous and exogenous factors (e.g., reactive oxygen species, radiation, chemotherapeutic agents, etc.). Current research has revealed that oocytes at various developmental stages are able to respond to various types of DNA damage, repairing DNA or initiating apoptosis through complex mechanisms. Primordial follicular oocytes are more susceptible to apoptosis induced by DNA damage than oocytes entering the growth stage. DNA damage is less likely to induce arrest of the meiotic maturation process in oocytes, however the developmental capacity of oocytes carrying DNA damage is significantly reduced. In clinical practice, aging, radiation and chemotherapy are common causes of oocyte DNA damage, reduced ovarian reserve and infertility in women. Therefore, various methods that can reduce DNA damage and enhance DNA repair in oocytes have been tried in an attempt to protect oocytes. In this review, we systematically summarize the mechanisms of DNA damage and repair in mammalian oocytes at various developmental stages and discuss their potential clinical value with the aim to provide new strategies for fertility protection.

Key words: oocytes, DNA damage, DNA repair, DNA damage response

Nan Zhang, Jue Zhang, Ge Lin. Advances in the study of DNA damage and repair in mammalian oocytes[J]. Hereditas(Beijing), 2023, 45(5): 379-394.

Figures/Tables 1

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