Hoxc13在毛囊发育中的作用

doi:10.3724/SP.J.1005.2010.00656

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HEREDITAS ›› 2010, Vol. 32 ›› Issue (7): 656-662.doi: 10.3724/SP.J.1005.2010.00656

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Hoxc13 and the development of hair follicle

WU Jiang-Hong^{1, 2}, YAN Zu-Wei^{2, 3}, Husile¹, ZHANG Wen-Guang^{1, 2}, LI Jin-Quan^{1, 2}

1. College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China; 2. Key Laboratory of Animal Genetics, Breeding and Reproduction of the Nei Mongol Autonomous Region, Hohhot 010018, China; 3. College of Science, Inner Mongolia Agricultural University, Hohhot 010018, China

Received:2009-10-10 Revised:2010-01-30 Online:2010-07-20 Published:2010-07-20
Contact: ZHANG Wen-Guang;LI Jin-Quan E-mail:atcgnmbi@yahoo.com.cn;atcgnmbi@yahoo.com.cn

Abstract

Abstract: Hoxc13 belongs to the Abd-B class of Hox gene family, which participated in the hair follicle formation and hair growth regulation process. The structural protein of hair KP (keratin) and KAP (keratin-associated protein) expression is under regulation of Hoxc13, and then changes the characteristics of hair by regulating the composition of these two types of hair proteins and maintaining the normal morphology of hair follicle. In this review, we summarized that the relationship between the expression level of Hoxc13 and hair follicle development/hair growth and the mechanisim under the controling of Hoxc13 and relevant genes.

Key words: Hoxc13, hair follicle, KP/KAP, genes pathway

TUN Jiang-Hong, YAN Jie-Wei, HU Shi-Le, ZHANG Wen-An, LI Jin-Quan. Hoxc13 and the development of hair follicle[J]. HEREDITAS, 2010, 32(7): 656-662.

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Hoxc13 and the development of hair follicle

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