卵巢低氧微环境调节哺乳动物排卵的分子机制

doi:10.16288/j.yczz.15-289

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HEREDITAS(Beijing) ›› 2016, Vol. 38 ›› Issue (2): 109-117.doi: 10.16288/j.yczz.15-289

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A mechanistic review of how hypoxic mircroenvironment regulates mammalian ovulation

Fang Yang¹, Baoyun Zhang¹, Guangde Feng², Wei Xiang¹, Yunxia Ma¹, Hang Chen¹, Mingxing Chu³, Pingqing Wang¹

1. College of Bioengineering, Chongqing University, Chongqing 400030, China;
2. Sichuan TQLS Animal Husbandry Science and Technology Co.LTD, Mianyang 621000, China;
3. Key Laboratory of Farm Animal Genetic Resources and Germplasm Innovation of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Received:2015-06-23 Revised:2015-09-08 Online:2016-02-20 Published:2015-12-03

Abstract

Abstract: Mammalian ovulation is a complicated process that includes development of follicles, ovulation, formation of corpus luteum and luteolysis. The three different stages of the ovulation activity are affected by hypoxic microenvironment and hypoxia-induced factors (HIF), which play a crucial role in physiologyical processes, such as angiogenesis and inflammation. Although the process of ovulation has been well elucidated, the molecular mechanism regulated by hypoxia needs an in depth study. In this review, we summarize how hypoxic and HIF regulate gene expression during mammalian ovulation in order to provide a better understanding of ovulation mechanism, which may lay a theoretical basis for prevention and therapy of various ovarian diseases.

Key words: mammals, ovulation, hypoxic microenvironment, hypoxia-inducible factors

Fang Yang, Baoyun Zhang, Guangde Feng, Wei Xiang, Yunxia Ma, Hang Chen, Mingxing Chu, Pingqing Wang. A mechanistic review of how hypoxic mircroenvironment regulates mammalian ovulation[J]. HEREDITAS(Beijing), 2016, 38(2): 109-117.

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A mechanistic review of how hypoxic mircroenvironment regulates mammalian ovulation

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