哺乳动物胰岛素样生长因子酸不稳定亚基的结构与功能

doi:10.16288/j.yczz.15-192

[an error occurred while processing this directive]

HEREDITAS(Beijing) ›› 2015, Vol. 37 ›› Issue (12): 1185-1193.doi: 10.16288/j.yczz.15-192

• Reviews • Previous Articles Next Articles

Structure and function of insulin-like growth factor acid-labile subunits in mammalian homologues

Guilin Li, Lili Niu, Haifeng Liu, Jiazhong Guo

College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China

Received:2015-05-04 Online:2015-12-20 Published:2015-09-23

Abstract

Abstract: Insulin-like growth factors (IGFs) act as a critical signaling pathway in animals and play significant roles in body growth, development, and occurrence and progression of animal diseases. In the past, structural and functional studies of ligands, receptors and even specific binding proteins in the IGFs system have been extensively investigated. However, the functional study of insulin-like growth factor acid-labile subunit (IGFALS) mainly focused on the prolonging half-life of IGFs. Increasing number of studies indicated that mutations in the IGFALS DNA sequence and low expression level of IGFALS proteins can lead to growth and development retardation in animals. In this review, we summarize recent structural and functional studies of IGFALS in mammals, aiming to further identify detailed genetic mechanism of IGFALS.

Key words: insulin-like growth factor acid-labile subunit, mutations, function, mammals

Guilin Li, Lili Niu, Haifeng Liu, Jiazhong Guo. Structure and function of insulin-like growth factor acid-labile subunits in mammalian homologues[J]. HEREDITAS(Beijing), 2015, 37(12): 1185-1193.

References

[1] Schlupf J, Steinbeisser H. IGF antagonizes the Wnt/β-Catenin pathway and promotes differentiation of extra-embryonic endoderm. Differentiation , 2014, 87(5): 209-219.
[2] Constância M, Hemberger M, Hughes J, Dean W, Ferguson-Smith A, Fundele R, Stewart F, Kelsey G, Fowden A, Sibley C, Reik W. Placental-specific IGF-II is a major modulator of placental and fetal growth. Nature , 2002, 417(6892): 945-948.
[3] Wang YM, Nishida S, Sakata T, Elalieh HZ, Chang WH, Halloran BP, Doty SB, Bikle DD. Insulin-like growth factor-I is essential for embryonic bone development. Endocrinology , 2006, 147(10): 4753-4761.
[4] Chen L, Jiang W, Huang JY, He BC, Zuo GW, Zhang WL, Luo Q, Shi Q, Zhang BQ, Wagner ER, Luo JY, Tang M, Wietholt C, Luo XJ, Bi Y, Su YX, Liu B, Kim SH, He CJ, Hu YW, Shen JK, Rastegar F, Huang EY, Gao YH, Gao JL, Zhou JZ, Reid RR, Luu HH, Haydon RC, He TC, Deng ZL. Insulin-like growth factor 2 (IGF-2) potentiates BMP-9-induced osteogenic differentiation and bone formation. J Bone Miner Res , 2010, 25(11): 2447-2459.
[5] Ibrahim YH, Yee D. Insulin-like growth factor-I and cancer risk. Growth Horm IGF Res , 2004, 14(4): 261-269.
[6] Ren J, Anversa P. The insulin-like growth factor I system: physiological and pathophysiological implication in cardiovascular diseases associated with metabolic syndrome. Biochem Pharmacol , 2015, 93(4): 409-417.
[7] Guler HP, Zapf J, Schmid C, Froesch ER. Insulin-like growth factors I and II in healthy man. Estimations of half-lives and production rates. Acta Endocrinol (Copenh) , 1989, 121(6): 753-758.
[8] Zapf J. Insulinlike growth factor binding proteins and tumor hypoglycemia. Trends Endocrinol Met , 1995, 6(2): 37-42.
[9] Leong SR, Baxter RC, Camerato T, Dai J, Wood WI. Structure and functional expression of the acid-labile subunit of the insulin-like growth factor-binding protein complex. Mol Endocrinol , 1992, 6(6): 870-876.
[10] Boisclair YR, Rhoads RP, Ueki I, Wang J, Ooi GT. The acid-labile subunit (ALS) of the 150 kDa IGF-binding protein complex: an important but forgotten component of the circulating IGF system. J Endocrinol , 2001, 170(1): 63-70.
[11] Dai J, Baxter RC. Molecular cloning of the acid-labile subunit of the rat insulin-like growth factor binding protein complex. Biochem Biophys Res Commun , 1992, 188(1): 304-309.
[12] Boisclair YR, Seto D, Hsieh S, Hurst KR, Ooi GT. Organization and chromosomal localization of the gene encoding the mouse acid labile subunit of the insulin-like growth factor binding complex. Proc Natl Acad Sci USA , 1996, 93(19): 10028-10033.
[13] Rhoads RP, Greenwood PL, Bell AW, Boisclair YR. Organization and regulation of the gene encoding the sheep acid-labile subunit of the 150-kilodalton insulin-like growth factor-binding protein complex. Endocrinology , 2000, 141(4): 1425-1433.
[14] Li S, Ren JF, Huang L. Characterization of the porcine insulin- like growth factor-binding protein , acid-labile subunit gene: full-length cDNA and DNA sequence, polymorphisms and expression profile. J Anim Breed Genet , 2007, 124(3): 133-138.
[15] Kim JW, Rhoads RP, Segoale N, Kristensen NB, Bauman DE, Boiselair YR. Isolation of the cDNA encoding the acid labile subunit (ALS) of the 150 kDa IGF-binding protein complex in cattle and ALS regulation during the transition from pregnancy to lactation. J Endocrinol , 2006, 189(3): 583-593.
[16] Lee DH, Chun C, Kim SH, Lee CY. Expression of porcine acid-labile subunit (pALS) of the 150-kilodalton ternary insulin-like growth factor complex and initial characterization of recombinant pALS protein. J Biochem Mol Biol , 2005, 38(2): 225-231.
[17] Janosi JB, Firth SM, Bond JJ, Baxter RC, Delhanty PJ. N-Linked glycosylation and sialylation of the acid-labile subunit. Role in complex formation with insulin-like growth factor (IGF)-binding protein-3 and the IGFs. J Biol Chem , 1999, 274(9): 5292-5298.
[18] Baxter RC, Martin JL, Beniac VA. H

Metrics

Comments

www.chinagene.cn
备案号：京ICP备09063187号

Structure and function of insulin-like growth factor acid-labile subunits in mammalian homologues

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Xiaohua Hao, Shuang Hu, Dan Zhao, Lianfu Tian, Zijing Xie, Sha Wu, Wenli Hu, Han Lei, Dongping Li. OsGA3ox genes regulate rice fertility and plant height by synthesizing diverse active GA [J]. Hereditas(Beijing), 2023, 45(9): 845-855.
[2]	Qianwen Lv, Yongfang Yang. The biological functions of peptide signaling in plant and the advances on its utilization for crop improvement [J]. Hereditas(Beijing), 2023, 45(9): 813-828.
[3]	Yang Yang, Mingxing Chu, Qiuyue Liu. The mechanism of circadian clock and its influence on animal circannual rhythm [J]. Hereditas(Beijing), 2023, 45(5): 409-424.
[4]	Rongrong Mu, Qingqing Niu, Yuqiang Sun, Jun Mei, Meng Miao. Cloning and characterization of the MYB transcription factor gene GhTT2 in Gossypium hirsutum [J]. Hereditas(Beijing), 2022, 44(8): 720-728.
[5]	Mingliang Jiang, Hong Lang, Xiaonan Li, Ye Zu, Jing Zhao, Shenling Peng, Zhen Liu, Zongxiang Zhan, Zhongyun Piao. Progress on plant orphan genes [J]. Hereditas(Beijing), 2022, 44(8): 682-694.
[6]	Xue Lv, Bangjie Li, Hanmei Xu. Research progress on high throughput discovery and functional verification of functional micropeptides [J]. Hereditas(Beijing), 2022, 44(6): 478-490.
[7]	Shaozheng Song, Zhengyi He, Yong Cheng, Baoli Yu, Ting Zhang, Dan Li. MSTN modification in goat mediated by TALENs and performance analysis [J]. Hereditas(Beijing), 2022, 44(6): 531-542.
[8]	Sinan Luan, Lele Liu, Jiayuan Zhou, Nurasya Imam, Minlong Cui, Chunlan Piao. Functional analysis of flower development related gene SvGLOBOSA from Senecio vulgaris [J]. Hereditas(Beijing), 2022, 44(6): 521-530.
[9]	Wandi Xiong, Kaiyu Xu, Lin Lu, Jiali Li. Research progress on lncRNAs in Alzheimer’s disease [J]. Hereditas(Beijing), 2022, 44(3): 189-197.
[10]	Jiayu Yu, Ting Chen, Zhihua Wang, Juan Zheng, Tianshu Zeng. Diagnosis, treatment and genetic analysis of a case of skin hyperpigmentation as the only manifestation with X-linked adrenoleukodystrophy [J]. Hereditas(Beijing), 2022, 44(10): 983-989.
[11]	Yingyun Gong, Zhenzhen Fu, Hongwen Zhou. Establishment and operation of glucose clamp technique in mice [J]. Hereditas(Beijing), 2022, 44(10): 967-974.
[12]	Shanshan Gao, Jinliang Li, Jiani Yang, Tong Zhou, Rui Liu, Xiaoping Wang, Li Yu. Progresses on adaptive evolution of gliding and flying ability in mammals [J]. Hereditas(Beijing), 2022, 44(1): 46-58.
[13]	Jie Yuan, Shiqing Cai. The regulatory mechanisms of behavioral and cognitive aging [J]. Hereditas(Beijing), 2021, 43(6): 545-570.
[14]	Hengxing Ba, Pengfei Hu, Chunyi Li. Progress on deer genome research [J]. Hereditas(Beijing), 2021, 43(4): 308-322.
[15]	Yidan Sun, Zizhao Tian, Wei Zhou, Mo Li, Cong Huai, Lin He, Shengying Qin. Genome-wide association study on liver function tests in Chinese [J]. Hereditas(Beijing), 2021, 43(3): 249-260.