MicroRNA调控哺乳动物骨骼肌发育

doi:10.16288/j.yczz.17-112

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Hereditas(Beijing) ›› 2017, Vol. 39 ›› Issue (11): 1046-1053.doi: 10.16288/j.yczz.17-112

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Advances on microRNA in regulating mammalian skeletal muscle development

Xinyun Li(),Liangliang Fu,Huijun Cheng,Shuhong Zhao()

Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education; Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture; the Coperative Innovation Center for Sustainable Pig Production; Huazhong Agricultural University, Wuhan 430070, China

Received:2017-03-29 Revised:2017-09-25 Online:2017-11-20 Published:2017-12-20
Supported by:
the National Natural Science Foundation of China(31672391, 31601920);the National High Technology Research and Development Program of China(2013AA102502)

Abstract

Abstract:

MicroRNA (miRNA) is a class of short non-coding RNA, which is about 22 bp in length. In mammals, miRNA exerts its funtion through binding with the 3°-UTR region of target genes and inhibiting their translation. Skeletal muscle development is a complex event, including: proliferation, migration and differentiation of skeletal muscle stem cells; proliferation, differentiation and fusion of myocytes; as well as hypertrophy, energy metabolism and conversion of muscle fiber types. The miRNA plays important roles in all processes of skeletal muscle development through targeting the key factors of different stages. Herein we summarize the miRNA related to muscle development, providing a better understanding of the skeletal muscle development.

Key words: miRNA, skeletal muscle, muscle progenitor cells, satellite cells, myocytes

Xinyun Li, Liangliang Fu, Huijun Cheng, Shuhong Zhao. Advances on microRNA in regulating mammalian skeletal muscle development[J]. Hereditas(Beijing), 2017, 39(11): 1046-1053.

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