circRNA及其调控动物骨骼肌发育研究进展

doi:10.16288/j.yczz.20-207

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Hereditas(Beijing) ›› 2020, Vol. 42 ›› Issue (12): 1178-1191.doi: 10.16288/j.yczz.20-207

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circRNA on animal skeletal muscle development regulation

Ting Zheng¹, Mailin Gan¹, Linyuan Shen¹, Lili Niu¹, Zongyi Guo², Jinyong Wang², Shunhua Zhang¹(), Li Zhu¹()

^1. College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China
^2. ChongQing Academy of Animal Sciences, Rongchang 402460, China

Received:2020-07-06 Revised:2020-10-13 Online:2020-12-17 Published:2020-12-01
Contact: Zhang Shunhua,Zhu Li E-mail:363445986@qq.com;zhuli7508@163.com
Supported by:
Supported by the National Natural Science Foundation of China No(31972524);Sichuan Pig Innovation Team Project of National Modern Agricultural Industrial Technology System(SCSZTD-3-008);the Science and Technology Program of Sichuan Province No(2016NYZ0050)

Abstract

Abstract:

Circular RNA (circRNA) is a type of closed circular RNA molecules formed by reverse splicing, which exists widely in organisms and has become a research hotspot in non-coding RNAs in recent years. Skeletal muscle plays the role of coordinating movement and maintaining normal metabolism and endocrine in organisms. With the development of sequencing and bioinformatics analysis technology, the functions and regulation mechanisms of circRNAs in skeletal muscle development have been gradually revealed. In this review, we summarize the types of molecular regulatory mechanisms, the classical research ideas and the functional research methods of circRNAs, and the research progress of circRNAs involved in normal development of skeletal muscle and regulation of skeletal muscle disease, in order to provide a reference to further study of the genetic mechanisms of circRNAs in the regulation of skeletal muscle development.

Key words: circRNA, skeletal muscle development, skeletal muscle diseases, RNA-seq

Ting Zheng, Mailin Gan, Linyuan Shen, Lili Niu, Zongyi Guo, Jinyong Wang, Shunhua Zhang, Li Zhu. circRNA on animal skeletal muscle development regulation[J]. Hereditas(Beijing), 2020, 42(12): 1178-1191.

Figures/Tables 4

Fig. 1

Fig. 2

circRNA		物种	可能作用机制	生物学功能
circZNF609	人(Homo sapiens)	编码蛋白质	促进成肌细胞增殖	[28]
circZNF609	小鼠(Mus musculus)	编码蛋白质	促进成肌细胞增殖	[28]
circLMO7	牛(Bos taurus)	吸附miR-378-3p,靶基因为HDAC4	促进成肌细胞增殖, 抑制分化和凋亡	[70]
circRBFOX2	鸡(Gallus gallus)	吸附miR-206,靶基因为CCND2	促进成肌细胞增殖	[74]
circFUT10	牛(Bos taurus)	吸附miR-133a,靶基因为SRF	抑制成肌细胞增殖, 促进成肌细胞分化	[75]
circSVIL	鸡(Gallus gallus)	吸附miR-203,靶基因为c-Jun、MEF2C	促进成肌细胞增殖、分化	[76]
circFGFR4	牛(Bos taurus)	吸附miR-107,靶基因为Wnt3a	促进成肌细胞分化,诱导凋亡	[49]
circZfp609	小鼠(Mus musculus)	吸附miR-194-5p,靶基因为BCLAF1	抑制成肌细胞分化	[77]
circHIPK3	鸡(Gallus gallus)	吸附miR-30a-3p,靶基因为MEF2C	促进成肌细胞增殖、分化	[50]
circFoxO3	小鼠(Mus musculus)	吸附miR-138-5p	抑制成肌细胞分化	[78]
circSNX29	牛(Bos taurus)	吸附miR-744,靶基因为Wnt5a	抑制成肌细胞增殖、促进成肌细胞分化	[79]
circTMTC1	鸡(Gallus gallus)	吸附miR-128-3p,靶基因为MSTN	抑制骨骼肌卫星细胞增殖、分化	[80]
circCDR1as	山羊(Capra hircus)	吸附miR-7,靶基因为IGF1R	促进骨骼肌卫星细胞成肌分化	[81]
circTTN	牛(Bos taurus)	吸附miR-432,靶基因为IGF2	促进成肌细胞增殖、分化	[82]
circHIPK3	小鼠(Mus musculus)	吸附miR-124-5p和miR-379-5p	促进成肌细胞分化	[83]
circTUT7	猪(Sus scrofa)	吸附miR-30a-3p,靶基因为HMG20B	促进胚胎肌生成相关基因转录	[73]
circINSR	牛(Bos taurus)	吸附miR-34a,靶基因为Bcl-2、CyclinE2	促进成肌细胞增殖、抑制凋亡	[51]
circHUWE1	牛(Bos taurus)	吸附miR-29b,靶基因为AKT3	促进成肌细胞增殖、抑制凋亡及分化	[84]
circSamd4	小鼠(Mus musculus)	与PUR蛋白结合	促进成肌细胞分化	[85]

Table 2

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circRNA	物种	组织/细胞	疾病类型	表达模式	参考文献
circQKI	人(Homo sapiens)	原代肌细胞	DMD	下调	[28]
circBNC2	人(Homo sapiens)	原代肌细胞	DMD	下调	[28]
circZFP609	人(Homo sapiens)	原代肌细胞	DMD	上调	[28]
circCDYL	人(Homo sapiens)	骨骼肌组织	DM1	上调	[103]
circHIPK3	人(Homo sapiens)	骨骼肌组织	DM1	上调	[103]
circRTN4-03	人(Homo sapiens)	骨骼肌/肌源性细胞	DM1	上调	[103]
circZFP609	人(Homo sapiens)	骨骼肌/肌源性细胞	DM1	上调	[103]
circCAMSAP1	小鼠(Mus musculus)	骨骼肌组织	DM1	上调	[102]
circHIPK3	小鼠(Mus musculus)	骨骼肌组织	DM1	上调	[102]
circNFATC3	小鼠(Mus musculus)	骨骼肌组织	DM1	上调	[102]
circZfp609	小鼠(Mus musculus)	骨骼肌组织	DM1	上调	[102]
circBBS9	小鼠(Mus musculus)	骨骼肌组织	Sarcopenia	下调	[104]
circCAMK2D	人(Homo sapiens)	心肌组织	HCM/DCM	下调	[94]
circTTN	人(Homo sapiens)	心肌组织	DCM	下调	[94]

circRNA on animal skeletal muscle development regulation

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