前噬菌体研究进展

doi:10.16288/j.yczz.20-355

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Hereditas(Beijing) ›› 2021, Vol. 43 ›› Issue (3): 240-248.doi: 10.16288/j.yczz.20-355

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Research progress of prophages

Chen Xuemei¹(), Wei Yunlin¹, Ji Xiuling¹()

¹ Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China

Received:2020-11-27 Online:2021-03-16 Published:2021-01-14
Supported by:
the National Natural Science Foundation of China(31860147);the National Natural Science Foundation of China(31700324)

Abstract

Abstract:

As the most abundant biological entities on earth, bacteriophages (phages) were considered as the antagonists of bacteria. With the rapid development of genomics and molecular biology technologies, a subtle and complex relationship between phages and their host bacteria has been uncovered. Prophage refers to an intracellular form of a bacteriophage, which is usually integrated into the hereditary material of the host. Prophage is ubiquitously distributed in bacterial genomes. It reproduces when the host does and can affect important biological properties of their bacterial hosts, such as virulence, biofilm formation and host immunity. Interestingly, prophages were also involved in regulating the lysogeny-lytic state by “monitoring” the quorum sensing of bacteria. Recently, anti-CRISPR proteins encoded by prophages were found, which attracts a lot of attention. In this review, we summarized the prediction, distribution, classification and functions of prophages to lay a foundation for further studying interactions between phages and bacteria.

Key words: prophage, virulence, anti-CRISPR protein, lysogenic conversion, quorum sensing

Chen Xuemei, Wei Yunlin, Ji Xiuling. Research progress of prophages[J]. Hereditas(Beijing), 2021, 43(3): 240-248.

Figures/Tables 2

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程序	更新年份	检测目标	蛋白注释功能	att位点预测功能	相似性匹配
PhiSpy	2012	前噬菌体	有	有	有
VirSorter	2015	病毒	-	-	有
PHASTER	2016	前噬菌体	有	有	有
VirFinder	2017	病毒	-	-	-
MetaPhinder	2016	噬菌体	-	-	有
MARVEL	2018	噬菌体	-	-	有
Prophage Hunter	2019	前噬菌体	有	有	有

Research progress of prophages

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