JAK/STAT信号通路及其对昆虫免疫的调控

doi:10.16288/j.yczz.22-402

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Hereditas(Beijing) ›› 2023, Vol. 45 ›› Issue (3): 229-236.doi: 10.16288/j.yczz.22-402

• Review • Previous Articles Next Articles

JAK/STAT signaling pathway and its regulation on insect immunity

Xiangyi Wei(), Dongchun Hu, Zupeng Gao, Congjing Feng()

College of Plant Protection, Yangzhou University, Yangzhou 225009, China

Received:2022-12-06 Revised:2023-01-10 Online:2023-03-20 Published:2023-02-15
Contact: Feng Congjing E-mail:weixiangyi1632@outlook.com;fengcj@yzu.edu.cn
Supported by:
the National Natural Science Foundation of China(32072417)

Abstract

Abstract:

JAK/STAT signaling pathway is involved in important biological processes, such as cell growth, differentiation, apoptosis and immune regulation, and is one of the most important signal transduction pathways mediated by cytokines. JAK/STAT is a relatively conserved signaling pathway in insects, which is the main immune pathway together with Toll signaling pathway and Imd signaling pathway to resist the invasion of pathogens. It plays a vital role in insect immunity, hormone regulation and other physiological regulation processes. In this review, we summarize the cytokine receptor superfamily, JAKs family, STATs family, JAK/STAT signaling pathway and its mechanism of negative feedback regulation. We analyze the important functions and the latest research progress of JAK/STAT signaling pathway in insect infected by parasites, viruses and fungi. Finally, we propose the remaining problems in the study of JAK/STAT signaling pathway, so as to provide direction and reference for further research in this field.

Key words: JAK/STAT, insect immunity, signal transduction, negative regulations, cytokine

Xiangyi Wei, Dongchun Hu, Zupeng Gao, Congjing Feng. JAK/STAT signaling pathway and its regulation on insect immunity[J]. Hereditas(Beijing), 2023, 45(3): 229-236.

Figures/Tables 2

References 53

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