G蛋白偶联受体相关分选蛋白功能特征与相关疾病研究进展

doi:10.16288/j.yczz.20-020

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Hereditas(Beijing) ›› 2020, Vol. 42 ›› Issue (8): 713-724.doi: 10.16288/j.yczz.20-020

• Review • Next Articles

G protein-coupled receptor-associated sorting proteins: function and relevant disorders

Min Zhang, Lihong Liang, Yajie Lu(), Xin Cao

Department of Medical Genetics, Nanjing Medical University, Nanjing 211166, China

Received:2020-02-19 Revised:2020-04-16 Online:2020-08-20 Published:2020-05-19
Contact: Lu Yajie E-mail:luyajie@njmu.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China No(31571302);Jiangsu Key Laboratory of Xenotransplantation

Abstract

Abstract:

G protein-coupled receptors (GPCRs), the largest family of membrane protein receptors, can be activated by a variety of ligands and participate in signaling transduction, and they are essential in the physiologic process in vivo. GPCR-associated sorting proteins (GASPs) play an important role in the post-endocytic sorting of GPCRs. They mediate the degradation or recycling pathway, and regulate cell signaling transduction and other biological processes. The functional defects of GASPs have been reported to be implicated in pathogenesis of some neurological diseases, tumors and deafness and so on. In this review, we summarize the GASPs’ function, GPCR-GASP interactions, GPCR sorting pathway and GASP-related signaling pathways implicated in the transcriptional regulation. It could help to understand the potential linkage between GASPs’ dysfunction and diseases, and provide a new approach and strategy for the treatment of GASP-related diseases.

Key words: G protein-coupled receptors (GPCRs), G protein-coupled receptor-associated sorting proteins (GASPs), signal transduction, disease

Min Zhang, Lihong Liang, Yajie Lu, Xin Cao. G protein-coupled receptor-associated sorting proteins: function and relevant disorders[J]. Hereditas(Beijing), 2020, 42(8): 713-724.

Figures/Tables 3

Fig. 1

Table 1

Fig. 2

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GASPs	别名	互作伴侣	结合位点			主要功能	参考文献
GASPs	别名	互作伴侣	氨基末端	羧基末端	GASP基序	主要功能	参考文献
GASP-1	PIPS/KIAA0443	GPCRs		√	√	参与转运和降解	[25]
		Period 1	√		√	与昼夜节律调控相关	[38]
		Gab 1	结合位点尚未明确			与生长发育相关	[39]
		Microtubules		√	√	维持细胞骨架相关	[32]
GASP-2	HIP15	GPCRs		√	√	参与转运和降解	[30]
		Htt		√		与亨廷顿舞蹈症相关	[40]
		Smoothened		√		参与Hedgehog信号通路	[41]
		mGluR5		√		与自闭症有关	[42]
GASP-3	P60TRP/BHLHB9	GPCRs		√	√	参与转运和降解	[28]
		PPP2R5E	结合位点尚未明确			与神经元的生长调节有关	[43]
		IPO5	结合位点尚未明确			与神经元的生长调节有关	[43]
GASP-5	ARMCX5	GPCRs		√	√	参与转运和降解	[28]
GASP-6	ALEX3/ARMCX3	Sox10		√		与转录有关	[44]
GASP-7	ALEX1/ARMCX1	GPCRs		√		参与转运和降解	[28]
GASP-7	ALEX1/ARMCX1	PP110	结合位点尚未明确			与肿瘤的发生和发展有关	[29]
GASP-8	SVH	P53		√		与肿瘤的发生和发展有关	[37]
GASP-9	ALEX2/ARMCX2	VIM	结合位点尚未明确			维持细胞骨架相关	[33]

G protein-coupled receptor-associated sorting proteins: function and relevant disorders

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