外显子拼接复合体塑造m6A表观转录组的形成

doi:10.16288/j.yczz.23-051

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Hereditas(Beijing) ›› 2023, Vol. 45 ›› Issue (6): 464-471.doi: 10.16288/j.yczz.23-051

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Exon junction complex modulates the formation of the m⁶A epitranscriptome

Penghui Song¹(), Lijuan Ma²(), Dong Yan¹()

1. State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, China
2. CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200032, China

Received:2023-03-09 Revised:2023-05-17 Online:2023-06-20 Published:2023-05-22
Contact: Yan Dong E-mail:21110700039@m.fudan.edu.cn;malijuan@cemps.ac.cn;yandong@fudan.edu.cn
Supported by:
National Natural Science Foundation of China(31970786);National Natural Science Foundation of China(32270868)

Abstract

Abstract:

N⁶-methyladenosine (m⁶A) is one of the most abundant chemical modifications in mRNA and plays essential roles in diverse physiological and pathological processes. m⁶A is highly enriched near stop codons and in long internal exons of mRNA, but the mechanism leading to this specific distribution has been unclear. Recently, three papers have solved this major problem by revealing that exon junction complexes (EJCs) act as m⁶A suppressors and shape the formation of the m⁶A epitranscriptome. Here, we briefly introduce the m⁶A pathway, elaborate the roles of EJC on the formation of m⁶A modification based on these results, and describe the effect of exon-intron structure on mRNA stability via m⁶A, which will help us better understand the latest progress in the m⁶A RNA modification field.

Key words: RNA modification, m⁶A, exon junction complexes, splicing, RNA stability

Penghui Song, Lijuan Ma, Dong Yan. Exon junction complex modulates the formation of the m⁶A epitranscriptome[J]. Hereditas(Beijing), 2023, 45(6): 464-471.

Figures/Tables 1

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Exon junction complex modulates the formation of the m⁶A epitranscriptome