Hereditas(Beijing) ›› 2023, Vol. 45 ›› Issue (11): 1018-1027.doi: 10.16288/j.yczz.23-236
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Progress on the non-canonical mismatch repair in Mycobacterium and its role in antibiotic resistance
Shasha Xiang(
), Jianping Xie()
- Institute of Modern Biopharmaceuticals, School of Life Sciences, Southwest University, Chongqing 400715, China
-
Received:2023-09-11Revised:2023-10-29Online:2023-11-20Published:2023-11-03 -
Contact:Jianping Xie E-mail:1977015429@qq.com;georgex@swu.edu.cn -
Supported by:National Natural Science Foundation of China(82072246)
Cite this article
Shasha Xiang, Jianping Xie. Progress on the non-canonical mismatch repair in Mycobacterium and its role in antibiotic resistance[J]. Hereditas(Beijing), 2023, 45(11): 1018-1027.
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Fig. 1
EndoMS/NucS sequence multiple sequence alignment and protein crystal map"
Fig. 1
Fig. 2
Non-Canonical MMR pathway model of Mycobacterium tuberculosis"
Fig. 2
Table 1
Summary of key components and functions of canonical mismatch repair and non-canonical mismatch repair"
| 修复类型 | 生物种类 | 关键成分 | 功能 |
|---|---|---|---|
| 细菌典型错配修复 | 大肠杆菌E. coli | MutS | 识别错配DNA |
| MutL | 下游介质 | ||
| MutH | 内切酶 | ||
| UvrD | 解旋酶 | ||
| Exo1/ExoX | 3′→5′核酸外切酶 | ||
| ExoVII/RecJ | 5′→3′核酸外切酶 | ||
| DNA聚合酶III | 聚合酶 | ||
| 甲基化酶Dam酶 | DNA甲基化酶 | ||
| SSB结合蛋白 | 稳定DNA的单链区域，增强DNA聚合酶的活性 | ||
| DNA连接酶 | 连接酶 | ||
| 真核生物典型错配修复 | 真核生物 | MutSα/MutSβ | 识别错配DNA |
| MutLα | 下游介质；核酸内切酶 | ||
| Exo1 | 外切酶 | ||
| DNA聚合酶δ | 聚合酶 | ||
| PCNA/RFC | 激活MutLα活性 | ||
| DNA连接酶 | 连接酶 | ||
| 非典型错配修复 | 分枝杆菌 | NucS | 识别错配碱基，核酸内切酶 |
| DnaE1聚合酶 | DNA聚合酶 |
Table 1
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