GLP-1受体激动剂治疗阿尔茨海默症的机制及相关研究进展

doi:10.16288/j.yczz.24-178

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Hereditas(Beijing) ›› 2024, Vol. 46 ›› Issue (12): 1017-1027.doi: 10.16288/j.yczz.24-178

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The mechanism and related research progress of GLP-1 receptor agonists in treating Alzheimer’s disease

Xiaocheng Zhu(), Yiwen Wang, Hongwen Zhou()

Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

Received:2024-06-17 Revised:2024-08-29 Online:2024-12-20 Published:2024-09-06
Contact: Hongwen Zhou E-mail:duanpingluchen@163.com;drhongwenzhou@njmu.edu.cn
Supported by:
National Key Research and Development Program of China(2018YFA0506904)

Abstract

Abstract:

GLP-1 receptor agonists are primarily used clinically for the treatment of type 2 diabetes and have the potential for weight loss, while they are currently expanding their horizons in the treatment of hypertension, non-alcoholic liver disease, depression, and neurodegenerative diseases. In particular, in the treatment of Alzheimer's disease, a large number of animal models and a handful of clinical studies have demonstrated the potential efficacy of GLP-1 receptor agonists, making it highly probable that they will become a new entrant in the drug list for Alzheimer's disease. At present, the research on the mechanism of GLP-1 receptor agonist in the treatment of Alzheimer's disease is mainly based on in-depth analysis of the pathogenesis of Alzheimer's disease and exploration of the mechanism of its comorbidity with diabetes. This article mainly reviews the latest advances in the mechanism of GLP-1 receptor agonists in the treatment of Alzheimer's disease, introduces the latest achievements in animal studies and clinical studies, and aims to provide reference for the subsequent relevant basic research and clinical application.

Key words: GLP-1 receptor agonists, Alzheimer’s disease, pharmacology

Xiaocheng Zhu, Yiwen Wang, Hongwen Zhou. The mechanism and related research progress of GLP-1 receptor agonists in treating Alzheimer’s disease[J]. Hereditas(Beijing), 2024, 46(12): 1017-1027.

Figures/Tables 1

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