肿瘤演化过程中的进化生态：概念、应用与创新

doi:10.16288/j.yczz.24-264

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Hereditas(Beijing) ›› 2025, Vol. 47 ›› Issue (2): 228-236.doi: 10.16288/j.yczz.24-264

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Evolutionary ecology in tumor evolution: concept, application and innovation

Can Liu¹^,²^,⁴(), Weiwei Zhai³^,⁴, Xuemei Lu¹^,²^,⁴()

1. Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China
2. Yunnan Key Laboratory of Biodiversity Information, Kunming 650201, China
3. Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
4. University of Chinese Academy of Sciences, Beijing 101408, China

Received:2024-09-13 Revised:2024-11-05 Online:2025-02-20 Published:2024-11-26
Contact: Xuemei Lu E-mail:liucan@mail.kiz.ac.cn;xuemeilu@mail.kiz.ac.cn
Supported by:
National Natural Science Foundation of China(32150006)

Abstract

Abstract:

Tumor itself is a complex microecosystem, with complex spatio-temporal dynamics and multi-dimensional interactions. Its unimaginable heterogeneity and evolvability have exceeded the cognition of traditional oncology medicine. How to systematically characterize the whole tumor cell ecosystem from the dynamics and interaction of material, energy and signal levels, in order to explore new cognition, new rules and new therapies for the occurrence and development of tumors, is a new proposition and goal of tumor ecology. In this review, we discuss the origin, occurrence and development of tumors from the perspective of evolutionary ecology. First, we discuss the application of some classical concepts of ecology with tumor evolution. Subsequently, through the integration of the frontier papers of tumor ecology, we highlight the importance of ecological interactions on the occurrence and development of tumors from multiple levels, such as between cancer cells, between cancer cells and other normal somatic cells, and the tumor ecosystem. Finally, we propose the concept of tumor cell ecosystem, discussed how to characterize the entire tumor ecosystem from the system theory and proposed possible innovative treatment directions.

Key words: tumor evolution, evolutionary ecology, ecological interaction, cell population dynamics, tumor ecosphere

Can Liu, Weiwei Zhai, Xuemei Lu. Evolutionary ecology in tumor evolution: concept, application and innovation[J]. Hereditas(Beijing), 2025, 47(2): 228-236.

Figures/Tables 1

References 63

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