UFMylation类泛素修饰在结核分枝杆菌感染免疫中的作用与机理

doi:10.16288/j.yczz.24-259

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Hereditas(Beijing) ›› 2025, Vol. 47 ›› Issue (5): 546-557.doi: 10.16288/j.yczz.24-259

• Review • Previous Articles Next Articles

The role and mechanism of UFMylation, a ubiquitin-like modification, in Mycobacterium tuberculosis infection immunity

Yiran Liao¹(), Qiao Zhang¹, Peibo Li²(), Jianping Xie¹^,²()

1. Institute of Modern Biopharmaceuticals, School of Life Sciences, Southwest University, Chongqing 400715, China
2. Chongqing Public Health Medical Center, Chongqing 400036, China

Received:2024-10-30 Revised:2024-12-31 Online:2025-01-06 Published:2025-01-06
Contact: Peibo Li, Jianping Xie E-mail:1668704934@qq.com;157318851@qq.com;georgex@swu.edu.cn
Supported by:
National Natural Science Foundation of China(82211530059);2023 Key Disciplines On Public Health Construction in Chongqing(CSTB2024NSCQ-MSX0703);Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau)(2023MSXM107)

Abstract

Abstract:

Ubiquitin-fold modifier 1 (FM1) is a ubiquitin-like type I protein widely present in prokaryote and most eukaryote. UFMylaiton, mediated by UFM1, is involved in the regulation of a variety of cellular biochemical processes. Recently, the importance of UFM1 system in endoplasmic reticulum homeostasis regulation has been gradually discovered and emphasized. Endoplasmic reticulum stress caused by Mycobacterium tuberculosis is an important link in the progression of tuberculosis, so UFM1 system is expected to become a new target for the development of anti-tuberculosis drugs. In this review, we provide a brief overview of the UFM1 system and UFMylation pathway, and summarize the recent advances in understanding UFM1’s role in ER homeostasis regulation and its potential value in TB treatment, with the aim of offering new insight and direction for developing novel therapeutic strategies against tuberculosis.

Key words: UFMylation, UFM1 system, tuberculosis

Yiran Liao, Qiao Zhang, Peibo Li, Jianping Xie. The role and mechanism of UFMylation, a ubiquitin-like modification, in Mycobacterium tuberculosis infection immunity[J]. Hereditas(Beijing), 2025, 47(5): 546-557.

Figures/Tables 3

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信号通路	通路功能	CDK5RAP3扮演的角色	参考文献
Wnt/β-catenin 信号通路	在胚胎发育、组织再生和干细胞维持的多个阶段发挥重要作用，其异常激活与多种类型的癌症相关	通过磷酸化GSK-3β抑制β-catenin，从而抑制胃癌发生	[29]
		通过Akt/GSK-3β使Wnt/β-catenin通路失活，从而抑制类甲状腺癌的发生	[30]
		通过抑制胃癌细胞AKT磷酸化抑制Wnt/β-catenin信号传导，从而抑制胃癌发生	[31]
蛋白激酶ERK信号通路	参与调控细胞周期和细胞分化，细胞响应外界刺激的必需途径	作为抑瘤因子，在ERK1/2信号通路调控下抑制胃癌干细胞样细胞的自我更新	[32]
血管内皮生长因子(VEGF) 信号通路	在血管的形成和生长过程中起着重要作用。VEGF在新生血管形成过程中诱导基因表达，调控血管通透性并促进细胞的迁移、增殖和存活	抑制AKT/HIF-1α/VEGFA信号传导，从而抑制胃神经内分泌癌血管生成	[33]
信号转导与转录激活因子3(STAT3)信号通路	调节细胞周期蛋白和抗凋亡因子，促进细胞增殖和存活	通过与TSPAN6相互作用调控STAT3信号通路，影响胶质母细胞瘤的恶性发展	[34]

类别	泛素/类泛素蛋白	靶向/编码蛋白病原体	蛋白功能	生理学效应	参考文献
宿主编码	USP18	淋巴细胞脉络丛脑膜炎病毒	去ISG化	调节干扰素信号传导	[56]
	USP18	水疱性口炎病毒	去ISG化	调节干扰素信号传导	[56]
	USP7	I型单纯疱疹病毒	去泛素化	稳定ICP0蛋白	[57]
	USP7	EB病毒	去泛素化	稳定EBNA1蛋白；调控其复制功能	[58]
	CYLD	不可分型流感嗜血杆菌	去泛素化	负调控NF-kB依赖性炎症	[59]
		肺炎链球菌		急性肺损伤，死亡率增加	[60]
		大肠杆菌		负调控NF-kB依赖性炎症	[61]
病原体编码	AvrA	沙门氏菌属	去泛素化	抑制宿主炎症反应	[62]
	SseL	沙门氏菌属	去泛素化	延缓巨噬细胞杀伤	[63]
	YopJ	耶尔森氏菌属	乙酰化、去泛素化、去SUMO化	抑制宿主炎症反应	[64]
	ChlaDub1 ChlaDub2	沙眼衣原体	去泛素化、去NEDD化	未知	[65]
	ElaD	大肠杆菌	去泛素化	未知	[66]

The role and mechanism of UFMylation, a ubiquitin-like modification, in Mycobacterium tuberculosis infection immunity

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