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HEREDITAS ›› 2011, Vol. 33 ›› Issue (11): 1185-1190.doi: 10.3724/SP.J.1005.2011.01185

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Length of cell cycle in neural development

GU Juan, CHEN Xiao-Ping   

  1. College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310014, China
  • Received:2011-01-19 Revised:2011-07-11 Online:2011-11-20 Published:2011-11-25
  • Contact: CHEN Xiao-Ping E-mail:chxp@zjut.edu.cn

Abstract: Neural development of mammals generates a series of morphological and functional alterations in neural precursors. The precursors change the length of cell cycle in the process. Importantly, the changes are related to cell fate determination. Cellular and environmental factors have been elucidated including cyclin complex, notch signal pathway, proneural gene target proteins, microtubule and motor proteins. In the cell-cycle length hypothesis, cell cycle length could influence the accumulation of cell fate determinants in precursors, which decides the final cell fate of daughter cells. This study summarizes recent advances in the field.

Key words: neural development, neural precursor, cell-cycle length, the cell-cycle length hypothesis, cell fate de-termination