超级增强子在肿瘤研究中的进展

doi:10.16288/j.yczz.18-152

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Hereditas(Beijing) ›› 2019, Vol. 41 ›› Issue (1): 41-51.doi: 10.16288/j.yczz.18-152

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Research progress of super enhancer in cancer

Zhiqiang Wu^1,²,Zeyun Mi³

^1. Department of Radiation Oncology, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, China;
^2. Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China;
^3. Department of Biochemistry and Molecular Biology, College of Basic Medical Science, Tianjin Medical University, Tianjin 300070, China

Received:2018-07-13 Revised:2018-09-21 Online:2019-01-20 Published:2018-11-05
Supported by:
[Supported by the National Natural Science Foundation of China (Nos. 81502660,31700144) and Tianjin Municipal Science and Technology Commission (Nos. 16JCQNJC10000, 17JCQNJC10600)]

Abstract

Abstract:

Super enhancers (SEs) are composed of clusters of enhancers in close genomic proximity. They constitute a large family of regulatory elements that specify gene expression patterns and cell identity. SE regions consist of unusually strong enrichment of binding sites for transcriptional factors, cofactors, and enhancers associated with epigenetic modifications. SEs play important roles in regulating the aberrant gene expression in tumor cells. Via SEs, cancer cells activate the expression of various oncogenes, and promote cell proliferation, invasion and migration properties. Hence suppression of SEs activities could inhibit the growth and survival of cancer cells. In this review, we summarize the fundamental principles, functions and regulation of super enhancers and therapeutic potential in targeting SEs in cancer cells, thereby introducing and providing new conceptions for development of antineoplastic drugs.

Key words: enhancer, super enhancer, transcription, cancer

Zhiqiang Wu, Zeyun Mi. Research progress of super enhancer in cancer[J]. Hereditas(Beijing), 2019, 41(1): 41-51.

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