关键词: 脂蛋白脂酶基因, 2型糖尿病, 多态性

Abstract:

Lipoprotein lipase is a central enzyme in the lipid metabolism, which catalyses the hydrolysis of the triacylglycerol component of chylomicrons and very low density lipoproteins, thereby providing fatty acids and monoacylglycerol for tissue utilisation. LPL gene mutation may affect the activity of LPL, and results in lipid metabolism disorder. It is associated with type 2 diabetes, hypertension, atherosclerosis, obesity and corony artery disease. Here we review the structure, function, expression regulation of the LPL gene along with its association with complex diseases.