遗传 ›› 2007, Vol. 29 ›› Issue (3): 269-269―275.doi: 10.1360/yc-007-0269

• 专论与综述 • 上一篇    下一篇

胞外Ca信号——动植物中的第一信使

赵昕1, 裴真明1,2, 何奕昆1   

  1. 1. 首都师范大学生命科学学院, 北京 100037;
    2. Department of Biology, Duke University, Durham NC27708

  • 收稿日期:2006-06-28 修回日期:2006-09-22 出版日期:2007-03-01 发布日期:2007-03-01
  • 通讯作者: 何奕昆

Extracellular Ca signaling——first messenger in animals and plants

ZHAO Xin1, PEI Zhen-Ming1,2, HE Yi-Kun1

  

  1. l. College of Life Science, Capital Normal University, Beijing 100037, China;
    2. Department of Biology, Duke University, Durham NC27708, USA
  • Received:2006-06-28 Revised:2006-09-22 Online:2007-03-01 Published:2007-03-01
  • Contact: HE Yi-Kun

摘要:

钙离子作为重要的胞内第二信使, 控制着许多细胞的功能, 人们对此已经研究得比较深入。然而最近发现的一些细胞表面胞外Ca2+探测器使我们想到是否在胞外环境中, 钙离子也具有信号分子的功能。钙离子传感器包括已经研究得比较清楚的胞外Ca2+敏感受体—最初从甲状旁腺分离的G-耦联蛋白受体(CaR), 另外, 还有其他受体、通道和膜蛋白也都对胞外[Ca2+]的变化很敏感。最近从拟南芥保卫细胞中克隆到一个胞外钙离子受体蛋白(CAS), 通过胞外钙离子的变化引起胞内钙离子信号。这些受体蛋白的克隆, 使人们确信Ca2+在细胞中可以发挥第一信使的功能。

关键词: Ca2+, 胞外Ca2+敏感受体(CaR), 胞外钙离子受体(CAS)

Abstract:

It is well known that calcium acts as a vital intracellular second messenger that governs a large array of cellular processes. However, the molecular identification of a receptor for extracellular Ca2+, the extracellular calcium-sensing receptor, has opened up the possibility that Ca2+might also function as a messenger outside the cell. In animals, the Ca2+ sensor is the well-characterized extracellular-Ca2+- sensing receptor (CaR), a G- protein -coupled receptor originally isolated from the parathyroid gland. In addition, other receptors, channels and membrane proteins are all sensitive to external Ca2+ fluctuations. Recently, Han et al have cloned a receptor protein for extracellular calcium in Arabidopsis, which plays a key role in Ca2+-induced stomatal closing. Thus, the cloning of these receptors has prompted the consideration of Ca2+ also functioning as a ‘first messenger’ in animals and plants.