遗传 ›› 2015, Vol. 37 ›› Issue (8): 741-755.doi: 10.16288/j.yczz.15-082
陈开旭1, 王为兰1, 张富春1, 郑秀芬1, 2, 3
收稿日期:2015-02-13
修回日期:2015-04-20
出版日期:2015-08-20
发布日期:2015-08-20
通讯作者:
张富春,教授,博士,研究方向：分子生物学。E-mail: zfcxj@sina.com作者简介:陈开旭,在读博士研究生,研究方向：群体遗传学。E-mail: chenkaixu@126.com
基金资助:Kaixu Chen1, Weilan Wang1, Fuchun Zhang1, Xiufen Zheng1, 2, 3
Received:2015-02-13
Revised:2015-04-20
Online:2015-08-20
Published:2015-08-20
摘要： 人类身高是由环境和遗传因素共同决定的,遗传学研究发现遗传因素对身高差异的影响更大。身高是典型的多基因遗传性状,科研人员试图运用传统的连锁分析和关联分析寻找和发现对人类身高具有显著影响的常见DNA序列变异,但进展缓慢。近年来,随着基因分型和DNA测序技术的发展,人类身高的遗传学研究取得了很多突破性进展。全基因组关联分析(GWAS)的应用,发现和证实了上百个与人类身高相关的单核苷酸多态性位点(SNPs),拓展了人们对人类生长和发育的相关遗传学认识,同时也为研究人类其他复杂性状提供了理论依据和借鉴。本文综述了人类身高的遗传学研究进展,探讨了目前该研究领域所存在的问题和未来发展方向,以期为今后人类身高相关的遗传学研究提供参考和借鉴。
陈开旭, 王为兰, 张富春, 郑秀芬. 人类身高的遗传学研究进展[J]. 遗传, 2015, 37(8): 741-755.
Kaixu Chen, Weilan Wang, Fuchun Zhang, Xiufen Zheng. Progress in genetic research of human height[J]. HEREDITAS(Beijing), 2015, 37(8): 741-755.
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