自噬在肝再生中的作用

doi:10.16288/j.yczz.15-162

遗传 ›› 2015, Vol. 37 ›› Issue (11): 1116-1124.doi: 10.16288/j.yczz.15-162

自噬在肝再生中的作用

王棋文^1,2,3,常翠芳^1,2,3,谷宁宁^1,2,3,潘翠云^1,2,3,徐存拴^1,2,3

1. 河南师范大学,生命科学学院,省部共建细胞分化调控国家重点实验室培育基地,新乡453007;
2. 河南师范大学,河南省生物工程重点实验室,新乡453007;
3. 河南师范大学,生物工程药物河南省工程实验室, 新乡453007

收稿日期:2015-04-16 修回日期:2015-07-24 出版日期:2015-11-20 发布日期:2015-08-07
通讯作者: 徐存拴,博士,教授,博士生导师,研究方向：肝再生的分子机理。E-mail: xucs@x263.net E-mail:wangqiwen123@hotmail.com
作者简介:王棋文,博士研究生,讲师,研究方向：肝再生的分子机理。Tel: 0373-3325654; E-mail: wangqiwen123@hotmail.com
基金资助:
国家重点基础研究发展计划（973计划）前期研究专项（编号：2012CB722304）,河南省重大科技攻关项目（编号：111100910600）,河南省高等学校重点科研项目计划（编号：15A180007）,河南师范大学青年科学基金项目（编号：2014QK29）和河南师范大学博士科研启动费支持课题（编号：qd14175）资助

Effect of autophagy on liver regeneration

Qiwen Wang^1,2,3,Cuifang Chang^1,2,3,Ningning Gu^1,2,3,Cuiyun Pan^1,2,3,Cunshuan Xu^1,2,3

1. State Key Laboratory Cultivation Base for Cell Differentiation Regulation, College of Life Science, Henan Normal University, Xinxiang 453007, China;
2. Henan Bioengineering Key Laboratory, Henan Normal University, Xinxiang 453007, China;
3. Henan Engineering Laboratory for Bioengineering and Drug Development, Henan Normal University, Xinxiang 453007, China

Received:2015-04-16 Revised:2015-07-24 Online:2015-11-20 Published:2015-08-07

摘要/Abstract

摘要： 自噬是存在于真核细胞内的一种溶酶体依赖性的降解途径,在肝脏生理和病理过程中发挥着重要作用。肝脏具有强大的再生能力,在受到急、慢性损伤时,残肝细胞将会被激活进入细胞周期进行细胞增殖,以补偿丢失的肝组织和恢复肝功能。文章阐述了各种类型损伤之后的肝再生与自噬的关系。在物理性、酒精、食源性等因素引起的肝损伤中,肝脏通过启动自噬来促进肝再生;在化学性损伤的肝再生模型中,自噬在其中的作用仍然有争议;在病毒感染之后的肝再生中,一些嗜肝病毒（如丙肝病毒和乙肝病毒等）反而利用自噬来促进病毒颗粒复制,抑制肝再生。对自噬和肝再生机制的研究,将有助于进一步阐明再生过程,为治疗肝脏疾病提供新方法。

关键词: 肝再生, 自噬, 肝脏功能, 肝损伤

Abstract: Autophagy is a lysosome-mediated degradation pathway, which plays an important role in hepatic physiological and pathological processes, in eukaryotic cells. The liver has a remarkable regenerative capacity. After acute or chronic injury, the residual hepatic cells can be activated to enter the cell-cycle for proliferation, in order to compensate for lost liver tissue and recover liver function. In this review, we summarize the relationship between liver regeneration (LR) after various types of injury and autophagy. For example, autophagy is activated to accelerate LR after physically, alcohol and food borne induced liver injury, while the role of autophagy in animal models of LR after chemical injury remains controversial. Autophagy can also be used to promote the replication of virus particles by some hepatotropic viruses (e.g., HBV, HCV) and inhibit LR after viral infection. Studies on mechanisms of autophagy and LR will contribute to clarify the regenerative process and provide new methods for the treatment of liver disease.

Key words: liver regeneration, autophagy, liver function, liver injury

王棋文,常翠芳,谷宁宁,潘翠云,徐存拴. 自噬在肝再生中的作用[J]. 遗传, 2015, 37(11): 1116-1124.

Qiwen Wang,Cuifang Chang,Ningning Gu,Cuiyun Pan,Cunshuan Xu. Effect of autophagy on liver regeneration[J]. HEREDITAS(Beijing), 2015, 37(11): 1116-1124.

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