自噬在肝再生中的作用

doi:10.16288/j.yczz.15-162

遗传 ›› 2015, Vol. 37 ›› Issue (11): 1116-1124.doi: 10.16288/j.yczz.15-162

自噬在肝再生中的作用

王棋文^1,2,3,常翠芳^1,2,3,谷宁宁^1,2,3,潘翠云^1,2,3,徐存拴^1,2,3

1. 河南师范大学,生命科学学院,省部共建细胞分化调控国家重点实验室培育基地,新乡453007;
2. 河南师范大学,河南省生物工程重点实验室,新乡453007;
3. 河南师范大学,生物工程药物河南省工程实验室, 新乡453007

收稿日期:2015-04-16 修回日期:2015-07-24 出版日期:2015-11-20 发布日期:2015-08-07
通讯作者: 徐存拴,博士,教授,博士生导师,研究方向：肝再生的分子机理。E-mail: xucs@x263.net E-mail:wangqiwen123@hotmail.com
作者简介:王棋文,博士研究生,讲师,研究方向：肝再生的分子机理。Tel: 0373-3325654; E-mail: wangqiwen123@hotmail.com
基金资助:
国家重点基础研究发展计划（973计划）前期研究专项（编号：2012CB722304）,河南省重大科技攻关项目（编号：111100910600）,河南省高等学校重点科研项目计划（编号：15A180007）,河南师范大学青年科学基金项目（编号：2014QK29）和河南师范大学博士科研启动费支持课题（编号：qd14175）资助

Effect of autophagy on liver regeneration

Qiwen Wang^1,2,3,Cuifang Chang^1,2,3,Ningning Gu^1,2,3,Cuiyun Pan^1,2,3,Cunshuan Xu^1,2,3

1. State Key Laboratory Cultivation Base for Cell Differentiation Regulation, College of Life Science, Henan Normal University, Xinxiang 453007, China;
2. Henan Bioengineering Key Laboratory, Henan Normal University, Xinxiang 453007, China;
3. Henan Engineering Laboratory for Bioengineering and Drug Development, Henan Normal University, Xinxiang 453007, China

Received:2015-04-16 Revised:2015-07-24 Online:2015-11-20 Published:2015-08-07

摘要/Abstract

摘要： 自噬是存在于真核细胞内的一种溶酶体依赖性的降解途径,在肝脏生理和病理过程中发挥着重要作用。肝脏具有强大的再生能力,在受到急、慢性损伤时,残肝细胞将会被激活进入细胞周期进行细胞增殖,以补偿丢失的肝组织和恢复肝功能。文章阐述了各种类型损伤之后的肝再生与自噬的关系。在物理性、酒精、食源性等因素引起的肝损伤中,肝脏通过启动自噬来促进肝再生;在化学性损伤的肝再生模型中,自噬在其中的作用仍然有争议;在病毒感染之后的肝再生中,一些嗜肝病毒（如丙肝病毒和乙肝病毒等）反而利用自噬来促进病毒颗粒复制,抑制肝再生。对自噬和肝再生机制的研究,将有助于进一步阐明再生过程,为治疗肝脏疾病提供新方法。

关键词: 肝再生, 自噬, 肝脏功能, 肝损伤

Abstract: Autophagy is a lysosome-mediated degradation pathway, which plays an important role in hepatic physiological and pathological processes, in eukaryotic cells. The liver has a remarkable regenerative capacity. After acute or chronic injury, the residual hepatic cells can be activated to enter the cell-cycle for proliferation, in order to compensate for lost liver tissue and recover liver function. In this review, we summarize the relationship between liver regeneration (LR) after various types of injury and autophagy. For example, autophagy is activated to accelerate LR after physically, alcohol and food borne induced liver injury, while the role of autophagy in animal models of LR after chemical injury remains controversial. Autophagy can also be used to promote the replication of virus particles by some hepatotropic viruses (e.g., HBV, HCV) and inhibit LR after viral infection. Studies on mechanisms of autophagy and LR will contribute to clarify the regenerative process and provide new methods for the treatment of liver disease.

Key words: liver regeneration, autophagy, liver function, liver injury

王棋文,常翠芳,谷宁宁,潘翠云,徐存拴. 自噬在肝再生中的作用[J]. 遗传, 2015, 37(11): 1116-1124.

Qiwen Wang,Cuifang Chang,Ningning Gu,Cuiyun Pan,Cunshuan Xu. Effect of autophagy on liver regeneration[J]. HEREDITAS(Beijing), 2015, 37(11): 1116-1124.

参考文献

[1] Riehle KJ, Dan YY, Campbell JS, Fausto N. New concepts in liver regeneration. J Gastroenterol Hepatol , 2011, 26(Suppl. 1): 203-212.
[2] Diehl AM, Chute J. Underlying potential: cellular and molecular determinants of adult liver repair. J Clin Invest , 2013, 123(5): 1858-1860.
[3] Lin T, Ibrahim W, Peng CY, Finegold MJ, Tsai RYL. A novel role of nucleostemin in maintaining the genome integrity of dividing hepatocytes during mouse liver development and regeneration. Hepatology , 2013, 58(6): 2176-2187.
[4] Haga S, Ozaki M, Inoue H, Okamoto Y, Ogawa W, Takeda K, Akira S, Todo S. The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide -dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation. Hepatology , 2009, 49(1): 204-214.
[5] 杨永华, 包勇, 姜小筱. 自噬与肿瘤防治新策略. 中国药理学与毒理学杂志, 2015, 29(2): 179-190.
[6] Zhu JJ, Lu TF, Yue S, Shen XD, Gao F, Busuttil RW, Kupiec-Weglinski JW, Xia Q, Zhai Y. Rapamycin protection of livers from ischemia and reperfusion injury is dependent on both autophagy induction and mammalian target of rapamycin complex 2-Akt activation. Transplantation , 2015, 99(1): 48-55.
[7] Xie F, Jia L, Lin MH, Shi Y, Yin JM, Liu Y, Chen DX, Meng QH. ASPP2 attenuates triglycerides to protect against hepatocyte injury by reducing autophagy in a cell and mouse model of non-alcoholic fatty liver disease. J Cell Mol Med , 2015, 19(1): 155-164.
[8] Williams JA, Ni HM, Haynes A, Manley S, Li Y, Jaeschke H, Ding WX. Chronic deletion and acute knockdown of parkin have differential responses to acetaminophen-induced mitophagy and liver injury in mice. J Biol Chem , 2015, 290(17): 10934-10946.
[9] Lan SH, Wu SY, Zuchini R, Lin XZ, Su IJ, Tsai TF, Lin YJ, Wu CT, Liu HS. Autophagy suppresses tumorigenesis of hepatitis B virus-associated hepatocellular carcinoma through degradation of microRNA-224. Hepatology , 2014, 59(2): 505-517.
[10] Hamasaki M, Furuta N, Matsuda A, Nezu A, Yamamoto A, Fujita N, Oomori H, Noda T, Haraguchi T, Hiraoka Y, Amano A, Yoshimori T. Autophagosomes form at ER-mitochondria contact sites. Nature , 2013, 495(7441): 389-393.
[11] Codogno P, Meijer AJ. Autophagy in the liver. J Hepatol , 2013, 59(2): 389-391.
[12] Czaja MJ, Ding WX, Donohue TM, Friedman SL, Kim JS, Komatsu M, Lemasters JJ, Lemoine A, Lin JD, Ou JJ, Perlmutter DH, Randall G, Ray RB, Tsung A, Yin XM. Functions of autophagy in normal and diseased liver. Autophagy , 2013, 9(8): 1131-1158.
[13] Levine B, Mizushima N, Virgin HW. Autophagy in immunity and inflammation. Nature , 2011, 469(7330): 323-335.
[14] Komatsu M. Liver autophagy: physiology and pathology. J Biochem , 2012, 152(1): 5-15.
[15] Czaja MJ. Functions of autophagy in hepatic and pancreatic physiology and disease. Gastroenterology , 2011, 140(7): 1895-1908.
[16] Michalopoulos GK. Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas. Am J Pathol , 2010, 176(1): 2-13.
[17] Merlen G, Gentric G, Celton-Morizur S, Foretz M, Guidotti JE, Fauveau V, Leclerc J, Viollet B, Desdouets C. AMPKα1 controls hepatocyte proliferation independently of energy balance by regulating Cyclin A2 expression. J Hepatol , 2014, 60(1): 152-159.
[18] Lehmann K, Tschuor C, Rickenbacher A, Jang JH, Oberkofler CE, Tschopp O, Schultze SM, Raptis DA, Weber A, Graf R, Humar B, Clavien PA. Liver failure after extended hepatectomy in mice is mediated by a p21-dependent barrier to liver regeneration. Gastroenterology , 2012, 143(6): 1609-1619.
[19] Hu W, Nevzorova YA, Haas U, Moro N, Sicinski P, Geng Y, Barbacid M, Trautwein C, Liedtke C. Concurrent Deletion of cyclin E1 and cyclin-dependent kinase 2 in hepatocytes inhibits DNA replication and liver regeneration in mice. Hepatology , 2014, 59(2): 651-660.
[20] Lin CW, Mo LR, Chen YS, Chen YJ, Kuo PL, Yu ML. Enhanced autophagy promotes liver regeneration and hepatocyte proliferatio

编辑推荐

Metrics

www.chinagene.cn
备案号：京ICP备09063187号-4
总访问:,今日访问:,当前在线:

自噬在肝再生中的作用

Effect of autophagy on liver regeneration

PDF (PC)

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	刘静, 易聪, 许师明. 蛋白质乙酰化修饰对自噬的调控作用[J]. 遗传, 2022, 44(1): 15-24.
[2]	马克学, 李睿, 郭芳莹, 宋鸽鸽, 吴萌, 陈广文, 刘德增. 细胞自噬基因Atg6在涡虫中枢神经系统再生中的功能研究[J]. 遗传, 2021, 43(8): 792-801.
[3]	周晨希, 李沫, 怀聪, 贺林, 秦胜营. 中国人群中抗结核药物引发肝损伤的易感基因标记研究[J]. 遗传, 2020, 42(4): 374-379.
[4]	李玉席, 李俊宏, 周大旺. Hippo信号通路与肝脏稳态调控及疾病发生[J]. 遗传, 2017, 39(7): 607-616.
[5]	王诗铭, 宋晓, 赵雪莹, 陈红岩, 王久存, 吴俊杰, 高志强, 钱吉, 白春学, 李强, 韩宝惠, 卢大儒. 自噬通路基因多态性与晚期非小细胞肺癌含铂化疗疗效的相关性分析[J]. 遗传, 2017, 39(3): 250-262.
[6]	曾笑威, 刘翠翠, 韩凝, 边红武, 朱睦元. 植物自噬的调控因子和受体蛋白研究进展[J]. 遗传, 2016, 38(7): 644-650.
[7]	王棋文, 靳伟, 常翠芳, 徐存拴. 基于IPA分析自噬对大鼠肝再生中树突状细胞的调节作用[J]. 遗传, 2015, 37(3): 276-282.
[8]	陈元渊, 陈红岩, 卢大儒. SNARE蛋白调控细胞自噬的分子机制[J]. 遗传, 2014, 36(6): 547-551.
[9]	孙源超, 秦训思, 陈宏, 沈伟. 细胞自噬发生的表观遗传调节[J]. 遗传, 2014, 36(5): 447-455.
[10]	陈科，程汉华，周荣家. 自噬与泛素化蛋白降解途径的分子机制及其功能[J]. 遗传, 2012, 34(1): 5-18.
[11]	王泽，文园园，程振朝，郭学强，张新胜，徐存拴. 新基因BM390716、BI274487和AA963863与大鼠再生肝8种细胞的细胞外基质代谢[J]. 遗传, 2011, 33(4): 378-388.
[12]	常翠芳，王改平，朱秋实，王磊，张富春，马纪，徐存拴. 大鼠再生肝8种细胞的丝氨酸族氨基酸代谢相关基因的转录谱[J]. 遗传, 2010, 32(8): 829-838.
[13]	王师尧，金巍娜，吴丹. 青少年型神经元蜡样脂褐质沉积病(JNCL)的发病机制[J]. 遗传, 2009, 31(8): 779-784.
[14]	李红蕾，陈晓光，张富春，马纪，徐存拴. 细胞外基质相关基因在大鼠肝再生中表达模式分析[J]. 遗传, 2008, 30(3): 333-340.
[15]	李玉昌，徐存拴，张云汉. 应用抑制性消减杂交技术克隆大鼠肝再生过程中特异表达基因[J]. 遗传, 2002, 24(2): 152-154.