遗传 ›› 2021, Vol. 43 ›› Issue (12): 1132-1141.doi: 10.16288/j.yczz.21-261

• 综述 • 上一篇    下一篇

炎性衰老在血液系统疾病中的研究进展

刘紫妍(), 高艾()   

  1. 首都医科大学公共卫生学院, 北京 100069
  • 收稿日期:2021-10-05 修回日期:2021-11-10 出版日期:2021-12-20 发布日期:2021-11-18
  • 通讯作者: 高艾 E-mail:18801197471@163.com;gaoai428@ccmu.edu.cn
  • 作者简介:刘紫妍,本科在读, 2016 级5年制预防医学。E-mail: 18801197471@163.com
  • 基金资助:
    国家自然科学基金项目资助(81773397);国家自然科学基金项目资助(82073520)

Progress on inflamm-aging in hematologic diseases

Liu Ziyan(), Gao Ai()   

  1. School of Public Health, Capital Medical University, Beijing 100069, China
  • Received:2021-10-05 Revised:2021-11-10 Online:2021-12-20 Published:2021-11-18
  • Contact: Gao Ai E-mail:18801197471@163.com;gaoai428@ccmu.edu.cn
  • Supported by:
    Supported by the National Natural Science Foundation of China(81773397);Supported by the National Natural Science Foundation of China(82073520)

摘要:

随着人类寿命不断增长,全球人口老龄化加剧,老年性疾病发病率也随之上升。炎性衰老(inflamm-aging)指机体随增龄出现的促炎状态升高的现象。研究表明,炎性衰老与心脑血管疾病、神经退行性病变以及骨关节病变具有一定关联,但其发生机制仍不明确,尤其在血液系统疾病方面的研究也较为少见。全身性炎症如何通过衰老引起造血障碍进而参与血液系统疾病的发生尚不明晰。本文主要从炎性衰老的发生机制、炎性衰老与血液系统疾病的关系等方面展开综述,旨在揭示炎性衰老在血液系统疾病中的可能作用机制,为血液系统疾病的防治策略提供借鉴和参考。

关键词: 炎性衰老, 造血功能障碍, 血液系统疾病

Abstract:

With the increasing human life expectancy, the aging of the global population is intensifying, and the incidence of senile diseases is rising accordingly. Inflamm-aging refers to the phenomenon that the body's pro-inflammatory state increases with age. Studies have shown that inflamm-aging is related to cardiovascular and cerebrovascular diseases, neurodegenerative diseases, and osteoarthropathy, but its mechanism is still unclear, especially in blood system diseases. How systemic inflammation causes hematopoietic disorders through aging and then participates in the occurrence of hematological system diseases remains unclarified. This article reviews the pathogenesis of inflamm-aging, and the relationship between inflamm-aging and hematological diseases. It aims to reveal the possible mechanism of inflamm-aging in hematological diseases and provides a reference for the prevention and treatment of hematological diseases.

Key words: Inflamm-aging, hematopoietic dysfunction, hematological system diseases