遗传 ›› 2023, Vol. 45 ›› Issue (3): 229-236.doi: 10.16288/j.yczz.22-402
韦湘怡(
), 胡冬春, 高祖鹏, 冯从经()
收稿日期:2022-12-06
修回日期:2023-01-10
出版日期:2023-03-20
发布日期:2023-02-15
通讯作者:
冯从经
E-mail:weixiangyi1632@outlook.com;fengcj@yzu.edu.cn
作者简介:韦湘怡，在读硕士研究生，专业方向：昆虫生理学。E-mail: 基金资助:
Xiangyi Wei(), Dongchun Hu, Zupeng Gao, Congjing Feng()
Received:2022-12-06
Revised:2023-01-10
Online:2023-03-20
Published:2023-02-15
Contact:
Feng Congjing
E-mail:weixiangyi1632@outlook.com;fengcj@yzu.edu.cn
Supported by:摘要：
JAK/STAT信号通路参与细胞的生长、分化、凋亡和免疫调节等重要的生物学过程，是细胞因子介导的最重要的信号转导途径之一。在昆虫中，JAK/STAT是一条相对保守的信号途径，与Toll途径和Imd途径共同作为主要免疫途径以抵御病原物入侵，在昆虫免疫、激素调控和其他生理调节过程中发挥着十分重要的作用。本文介绍了细胞因子受体超家族、JAKs家族、STATs家族和JAK/STAT信号通路及其负反馈调节的作用机制，分析了寄生物、病毒和真菌感染昆虫时，JAK/STAT信号通路的重要功能及最新研究进展，并提出了JAK/STAT信号通路研究中尚待解决的问题，以期为该领域后续深入研究提供方向和参考。
韦湘怡, 胡冬春, 高祖鹏, 冯从经. JAK/STAT信号通路及其对昆虫免疫的调控[J]. 遗传, 2023, 45(3): 229-236.
Xiangyi Wei, Dongchun Hu, Zupeng Gao, Congjing Feng. JAK/STAT signaling pathway and its regulation on insect immunity[J]. Hereditas(Beijing), 2023, 45(3): 229-236.
图1
JAKs和STATs结构域 A：JAKs结构域；B：STATs结构域。"
图2
JAK/STAT信号途径 A：以果蝇为代表的昆虫JAK/STAT信号途径；B：哺乳动物JAK/STAT信号途径(主要包括细胞因子、生长因子和生长激素3种配体及其受体的激活信号)。"
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