遗传 ›› 2011, Vol. 33 ›› Issue (2): 117-122.doi: 10.3724/SP.J.1005.2011.00117

• 综述 • 上一篇    下一篇

前列腺癌中TMPRSS2-ETS基因融合及机制研究进展

郭晓强1, 2 , 桂耀庭1 , 蔡志明1   

  1. 1. 北京大学深圳医院, 广东省和深圳市男性生殖与遗传重点实验室, 深圳 518036; 
    2. 解放军白求恩军医学院生化教研室, 石家庄 050081
  • 收稿日期:2010-05-05 修回日期:2010-07-20 出版日期:2011-02-20 发布日期:2011-02-25
  • 通讯作者: 蔡志明 E-mail:caizhiming2000@yahoo.com.cn
  • 基金资助:

    深圳市重点实验室提升计划项目(编号:CXB200903090055A)资助

The progress of TMPRSS2-ETS gene fusions and their mechanism in prostate cancer

GUO Xiao-Qiang1, 2, GUI Yao-Ting1, CAI Zhi-Ming1   

  1. 1. The Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen 518036, China; 
    2. Department of Biochemistry, Bethune Military medical College, Shijiazhuang 050081, China
  • Received:2010-05-05 Revised:2010-07-20 Online:2011-02-20 Published:2011-02-25
  • Contact: CAI Zhi-Ming E-mail:caizhiming2000@yahoo.com.cn

摘要: 超过50%的前列腺癌中存在跨膜丝氨酸蛋白酶2(TMPRSS2)和E26(ETS)转录因子间的基因融合, 其中 TMPRSS2-ERG最为常见。TMPRSS2-ERG基因融合造成的ERG过表达参与了前列腺的癌变。雄激素受体结合和遗传毒性胁迫共同诱导了染色体的靠近和TMPRSS2-ETS的基因融合。TMPRSS2-ERG基因融合可作为前列腺癌诊断的一种生物标志物, 并可通过病人尿液检测来实现。文章对TMPRSS2-ETS基因融合的特征、融合及致癌及临床应用进行了综述。

关键词: 前列腺癌, 基因融合, 跨膜丝氨酸蛋白酶2, E26, 融合机制

Abstract: The gene fusions between transmembrane protease serine 2 (TMPRSS2) and E26 (ETS) transcription factors are present in over 50% of patients with prostate cancer. TMPRSS2-ERG is the most common gene fusion type. The ERG overexpression induced by TMPRSS2-ERG gene fusion contributes to the development of prostate cancer. Both androgen receptor binding and genotoxic stress induce chromosomal proximity and TMPRSS2-ETS gene fusions. TMPRSS2-ERG gene fusion functions as a biomarker for prostate cancer, which can be easily detected in urine. This review focuses on the characteristics, oncogenic and rearranged mechanism, and clinical application of TMPRSS2-ETS gene fusions.

Key words: prostate cancer, gene fusion, transmembrane protease serine 2 (TMPRSS2), E26, rearranged mechanism