遗传 ›› 2014, Vol. 36 ›› Issue (9): 871-878.doi: 10.3724/SP.J.1005.2014.0871
李园园1, 2, 郭磊2, 卢晟盛1, 韩之明2
收稿日期:
2014-04-29
出版日期:
2014-09-20
发布日期:
2014-09-20
通讯作者:
韩之明,博士,副研究员,专业方向:发育生物学。E-mail: hanzm@ioz.ac.cn
E-mail:liyuanyuan16@sina.cn
作者简介:
李园园,硕士研究生,专业方向:发育生物学。
基金资助:
Yuanyuan Li1, 2, Lei Guo2, Shengsheng Lu1, Zhiming Han2
Received:
2014-04-29
Online:
2014-09-20
Published:
2014-09-20
摘要: 甲状旁腺激素样激素(Parathyroid hormone-like hormone, PTHLH)又称为甲状旁腺激素相关蛋白(Parathyroid hormone-related protein, PTHrP),发现初期被认为是引起人类恶性肿瘤伴发的高钙血症的主要原因。进一步的研究发现,PTHLH在不同物种的多种成体和胎儿组织中均有表达,其生物学作用涉及形态发生、细胞生长与分化的调控、胎盘钙的转运等多个方面。文章主要综述了PTHLH的生物学特性及其在胚胎发育过程中的作用,并进一步探讨了涉及的信号通路及可能的作用机制。
李园园, 郭磊, 卢晟盛, 韩之明. 甲状旁腺激素样激素在胚胎发育中的作用[J]. 遗传, 2014, 36(9): 871-878.
Yuanyuan Li, Lei Guo, Shengsheng Lu, Zhiming Han. Role of parathyroid hormone-like hormone during embryonic development[J]. HEREDITAS(Beijing), 2014, 36(9): 871-878.
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