遗传 ›› 2002, Vol. 24 ›› Issue (1): 11-13.

• 论文 • 上一篇    下一篇

云南人群系统性红斑狼疮与TNF微卫星基因座关系的研究

初正韬;孙浩;钱亚屏;史磊;俞建昆;褚嘉祐 CHU Zheng-tao;SUN Hao;QIAN Ya-ping;SHI Lei;YU Jian-kun;CHU Jia-you   

  1. 中国协和医科大学中国医学科学院医学生物学研究所,昆明 650118 Institute of Medical Biology,Chinese Academy of Medical Sciences and Peking Medical College,Kunming 650118,China
  • 收稿日期:1900-01-01 出版日期:2002-02-10 发布日期:2002-02-10

The Relation Between TNF Microsatellite Loci Polymorphism and Systemic Lupus Erythematosus in Yunnan People

  • Received:1900-01-01 Online:2002-02-10 Published:2002-02-10

摘要: 位于MHC内的肿瘤坏死因子(tomornecrosisfactor,TNF)基因区域有5个微卫星基因座a、b、c、d和e,本研究调查了中国云南汉族系统性红斑狼疮(systemiclupuserythematosus,SLE)与这几个微卫星基因座多态性的关系。本文用荧光标记引物和半自动基因扫描方法对云南地区97例SLE患者及79例健康对照者的这5个微卫星基因座进行了基因分型,结果发现,SLE患者的TNFa1(P=0.0206),c2(P=0.0000)等位基因频率较正常人显著增高,而TNFa2(P=0.0163),c3(P=0.0065),c4(P=0.0012),d6(P=0.0448)等位基因频率则是正常对照较SLE患者高。同时我们还发现在这5个微卫星基因座中,与白种人比较中国人出现了尚未发现的新等位基因。
Abstract:We have investigated TNF microsatellite polymorphism in SLE.A total of 97 Chinese Han SLE patients and 79 matched Chinese Han controls were studied in this study, TNF microsatellites a,b,c,d and e were typed using fluorescent labeled automated genescanning and genotyping.TNFa1(P=0.0206),c2 (P=0.0000) allele frequencies were significantly increased in the SLE group comparing with controls,and TNF a2 (P=0.0163) c3(P=0.0065),c4(P=0.0012),d6(P=0.0448) allele frequencies were significantly increased in controls.Meanwhile,we found some new alleles in Chinese which are different form those in Caucasoids.

关键词: SLE, SLE, TNF, 基因扫描 Keywords, 微卫星基因座