Correlation study between Physical performance and gene has become a hot topic. Evidences have indicated that human capacity is partially influenced by genetic factors. Since 2000, the genetic studies of locomotion have progressed rapidly. More than 70 genetics markers associated with physical performance have been studied, such as VO_2max(maximal oxygen uptake), muscle strength and lactate threshold. This research could be used to detect the special individual in spaceflight project and national defense project. Obviously, genetic detection of the special individual at early stage will save time and fund as compared with traditional training system. The present paper is to summarize some major international studies on aerobic exercise related genes and loci. We expect that the present article may provide helpful information to promote the project in China.